Neurocognitive performances in participants of at-risk mental state for schizophrenia and in first-episode patients

Journal of Clinical and Experimental Neuropsychology
Seza OzgürdalGeorg Juckel

Abstract

As suggested by the neurodevelopmental model, neurocognitive disturbances are core features of schizophrenia spectrum disorders. The aim of the present study was to explore the neurocognitive performance of symptomatically defined high-risk participants as well as first-episode patients on tests of verbal memory, executive functioning, working memory, and attention. The sample consisted of 54 participants at risk for schizophrenia and 37 patients with a first episode of psychosis. The high-risk group exhibited a similar cognitive performance profile to that of the first-episode participants when compared with normative data. The neurocognitive functioning of both patient groups were within standard average range at most of the cognitive domains. Moreover the intellectual functioning of both groups was within higher average level, while decreased "hit rates" could be observed within both subtests "Figures" and "Symbols" of the Continuous Performance Test-Identical Pairs Version (CPT-IP) in the group of first-episode patients. Direct comparison between the clinical groups did show increasing impairments of these parameters in first-episode patients compared to high-risk participants. Results suggest that high-risk participants do...Continue Reading

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Citations

Apr 21, 2010·Neurotoxicity Research·Ralf Pukrop, Joachim Klosterkötter
Oct 8, 2014·Acta Neuropsychiatrica·Tina GoorenPeter Neu
Nov 24, 2012·Epidemiology and Psychiatric Sciences·J Addington, M Barbato
Aug 12, 2014·Psychiatry Research·Somaye ArabzadehFatemeh Rahiminejad
Mar 11, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Christoph U CorrellBarbara A Cornblatt
Nov 24, 2020·Neuropsychology Review·Rashina D Seabury, Tyrone D Cannon
Feb 7, 2021·Schizophrenia Bulletin·Mathilde AntoniadesAndré Schmidt

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