NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish.

Mechanisms of Development
Malgorzata J Ochocinska, Peter F Hitchcock

Abstract

neuroD is a member of the family of proneural genes, which function to regulate the cell cycle, cell fate determination and cellular differentiation. In the retinas of larval and adult teleosts, neuroD is expressed in two populations of post-mitotic cells, a subset of amacrine cells and nascent cone photoreceptors, and proliferating cells in the lineages that give rise exclusively to rod and cone photoreceptors. Based on previous studies of NeuroD function in vitro and the cellular pattern of neuroD expression in the zebrafish retina, we hypothesized that within the mitotic photoreceptor lineages NeuroD selectively regulates aspects of the cell cycle. To test this hypothesis, gain and loss-of-function approaches were employed, relying on the inducible expression of a NeuroD(EGFP) fusion protein and morpholino oligonucleotides to inhibit protein translation, respectively. Conditional expression of neuroD causes cells to withdraw from the cell cycle, upregulate the expression of the cell cycle inhibitors, p27 and p57, and downregulate the cell cycle progression factors, Cyclin B1, Cyclin D1, and Cyclin E2. In the absence of NeuroD, cells specific for the rod and cone photoreceptor lineage fail to exit the cell cycle, and the numb...Continue Reading

References

Sep 4, 1995·The Journal of Comparative Neurology·P A RaymondG A Curran
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·G A HyattJ E Dowling
Feb 1, 1997·Current Opinion in Neurobiology·J E Lee
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·H MutohA B Leiter
Sep 11, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V KorzhZ Gong
Feb 13, 1999·The Journal of Comparative Neurology·E A Schmitt, J E Dowling
Apr 15, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J K LeeH Suh-Kim
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Mar 17, 2001·Nature Reviews. Neuroscience·F J Livesey, C L Cepko
May 2, 2001·Nature Reviews. Neuroscience·M A Dyer, C L Cepko
Dec 12, 2001·Seminars in Cell & Developmental Biology·M L Vetter, N L Brown
Feb 19, 2002·Mechanisms of Development·Scott R BlechingerPatrick H Krone
Feb 21, 2002·Vision Research·Jarema J MalickiXiangyun Wei
Jul 3, 2002·Nature Reviews. Neuroscience·Nicolas BertrandFrançois Guillemot
Jan 25, 2003·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Dec 24, 2003·Investigative Ophthalmology & Visual Science·Run-Tao Yan, Shu-Zhen Wang
Mar 27, 2004·Endocrinology·Susan E SchonhoffAndrew B Leiter
Apr 24, 2004·The Journal of Biological Chemistry·Tadamichi AkagiRyoichiro Kageyama
Jul 13, 2004·Brain Research. Developmental Brain Research·Andréanne Bédard, André Parent
Jul 29, 2004·The Journal of Comparative Neurology·Peter Hitchcock, Laura Kakuk-Atkins
Dec 18, 2004·Methods in Cell Biology·Bernard ThisseChristine Thisse
Apr 28, 2005·Developmental Neuroscience·Terence J Van Raay, Monica L Vetter
Oct 11, 2005·Molecular Neurobiology·Run-Tao YanShu-Zhen Wang
Apr 11, 2006·Developmental Biology·Zac PujicJarema Malicki

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Citations

Sep 1, 2012·PLoS Computational Biology·Guillaume SalbreuxDavid K Lubensky
Jan 15, 2014·Progress in Retinal and Eye Research·Jenny R Lenkowski, Pamela A Raymond
Aug 19, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Susov DhakalDeborah L Stenkamp
Jan 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Aikaterini Bilitou, Shin-ichi Ohnuma
Jun 12, 2013·Developmental Biology·Marie A Forbes-OsborneAnn C Morris
May 9, 2012·Progress in Retinal and Eye Research·Ohad ShahamRuth Ashery-Padan
Jul 12, 2011·Progress in Retinal and Eye Research·Deborah L Stenkamp
Jan 8, 2019·Developmental Neurobiology·Scott M TaylorPeter F Hitchcock
Jun 19, 2019·Stem Cells and Development·Ratnesh K SinghIgor O Nasonkin
Nov 24, 2015·Annual Review of Vision Science·Constance L Cepko
Mar 27, 2018·Molecular Neurobiology·Luana de Almeida-PereiraLucianne Fragel-Madeira
Dec 16, 2020·PLoS Computational Biology·Hayden NunleyDavid K Lubensky
Sep 1, 2020·Experimental Eye Research·Jing LuYan Luo
Feb 2, 2021·Science China. Life Sciences·Shaojun WangGuang-Hua Peng
Nov 30, 2019·Developmental Biology·Dylan R FarnsworthAdam C Miller
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Susov DhakalDeborah L Stenkamp
May 15, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tsubasa ItohTakashi Shimizu

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