PMID: 9556024Apr 29, 1998Paper

Neurodegeneration and aging: role of the second genome

Journal of Neuroscience Research
M B GraeberS Kösel

Abstract

The latest Health Report of the World Health Organization predicts a significant increase in the age of human populations over the next two decades. In the developed world, at least 20% of the population will be older than 65 years. This development together with the as yet unknown etiology of many neurodegenerative disorders has caused an increased interest in the biology and pathophysiology of mitochondria. Dysfunction of mitochondria has been linked to both normal aging and neurodegenerative disorders, with the latter occurring much more frequently at higher age. Specifically, genetic defects in mitochondria have been shown to accumulate during life, and certain mutations of mitochondrial genes have been implicated in the etiology of Parkinson's and Alzheimer's diseases. In addition, a large number of new mitochondrial diseases have been identified following the first description of mitochondrial mutations 10 years ago. While there can be little doubt that DNA defects of mitochondria play a role in aging, specific mutations of mitochondrial genes underlying Parkinson's or Alzheimer's diseases remain to be identified. There is evidence, however, that mutations of the mitochondrial genome may increase the susceptibility to neu...Continue Reading

Citations

Aug 23, 2007·The British Journal of Dermatology·M Yaar, B A Gilchrest
Sep 28, 2005·Neurochemical Research·V G NicolettiA M Giuffrida Stella
May 10, 2006·Genes, Brain, and Behavior·M GrazinaC Oliveira
Oct 19, 2007·Zeitschrift für Gerontologie und Geriatrie·C Meissner
Jul 31, 2003·Journal of Neurochemistry·Fumiyuki HattoriShinzo Oikawa
Jan 5, 2000·Physiological Reviews·D G Nicholls, S L Budd
Jul 10, 2018·International Journal of Geriatric Psychiatry·Gregory J TranahUNKNOWN Health, Aging and Body Composition Study
Dec 28, 2002·Journal of Neuroscience Research·Alexandra Stolzing, Tilman Grune

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