Neurodegeneration, Heterochromatin, and Double-Stranded RNA

Journal of Experimental Neuroscience
Tassa K SaldiChristopher D Link

Abstract

Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.

References

Aug 13, 2013·Neuron·Shuo-Chien LingDon W Cleveland
Jan 28, 2014·Nature Neuroscience·Bess FrostMel B Feany
Jan 5, 2016·Current Biology : CB·Bess FrostMel B Feany
Jun 24, 2017·Human Molecular Genetics·Mercedes PrudencioChristopher D Link
Sep 25, 2017·Biochemistry. Biokhimii︠a︡·M S ProtasovaT V Andreeva
Jun 7, 2018·Cell Reports·Caiwei GuoJoshua M Shulman

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Citations

Feb 17, 2021·Nature Communications·Steve RodriguezArtem Sokolov
May 18, 2021·Frontiers in Aging Neuroscience·Nicolás W MartinezSoledad Matus
Jul 9, 2021·Science Translational Medicine·Steven RodriguezMark W Albers
Jul 3, 2021·Current Molecular Pharmacology·Vishal ChavdaBipin Chaurasia
Jul 13, 2019·Environmental Research·Lilian Calderón-GarcidueñasAngélica González-Maciel

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Methods Mentioned

BETA
ChIP-seq
immunoprecipitation
transgenic
RNA-seq

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