Neurodegeneration: paying it off with sleep

Current Biology : CB
Alex C Keene, William J Joiner

Abstract

A new study in fruit flies suggests modulation of neural activity links sleep and Alzheimer's disease. Both sleep loss and amyloid beta increase neural excitability, which reinforces the accumulation of amyloid beta and shortens lifespan.

References

Apr 3, 2003·Neuron·Flavio KamenetzRoberto Malinow
Jun 28, 2005·Sleep Medicine·Maria MoranB A Lawlor
Dec 21, 2005·Neuron·John R CirritoDavid M Holtzman
Sep 20, 2008·Nature Reviews. Neuroscience·Lars Bertram, Rudolph E Tanzi
May 3, 2011·Nature Neuroscience·Adam W BeroDavid M Holtzman
Jul 26, 2011·Cell·Amita Sehgal, Emmanuel Mignot
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Pascal E SanchezLennart Mucke
Oct 19, 2013·Science·Lulu XieMaiken Nedergaard
Dec 24, 2013·Neuron·Clifford R Jack, David M Holtzman
Jun 25, 2014·Frontiers in Aging Neuroscience·Brian Spencer, Eliezer Masliah
Nov 26, 2014·The Journal of Experimental Medicine·Jee Hoon RohDavid M Holtzman
Mar 11, 2015·Current Biology : CB·Masashi TabuchiMark N Wu

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Citations

Sep 22, 2020·Sleep Medicine·Siaw Cheok Liew, Thidar Aung
Jun 25, 2021·Frontiers in Neurology·Ibrahim MortadaNajwane Said Sadier

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