Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Amna AkhtarMuhammad Yar

Abstract

The central nervous system (CNS) encompasses the brain and spinal cord and is considered the processing center and the most vital part of human body. The central nervous system (CNS) barriers are crucial interfaces between the CNS and the periphery. Among all these biological barriers, the blood-brain barrier (BBB) strongly impede hurdle for drug transport to brain. It is a semi-permeable diffusion barrier against the noxious chemicals and harmful substances present in the blood stream and regulates the nutrients delivery to the brain for its proper functioning. Neurological diseases owing to the existence of the BBB and the blood-spinal cord barrier have been terrible and threatening challenges all over the world and can rarely be directly mediated. In fact, drug delivery to brain remained a challenge in the treatment of neurodegenerative (ND) disorders, for these different approaches have been proposed. Nano-fabricated smart drug delivery systems and implantable drug loaded biomaterials for brain repair are among some of these latest approaches. In current review, modern approaches developed to deal with the challenges associated with transporting drugs to the CNS are included. Recent studies on neural drug discovery and inje...Continue Reading

References

May 18, 2001·The New England Journal of Medicine·S B Prusiner
Feb 23, 2002·Drug Development and Industrial Pharmacy·P R LockmanD D Allen
Oct 11, 2003·Anti-cancer Drugs·Erin A BohulaValentine M Macaulay
Mar 3, 2004·Molecular Interventions·William M Pardridge
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Oct 26, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Celeste RoneyTejraj M Aminabhavi
Jan 13, 2006·British Journal of Pharmacology·Sian-Marie LucasRosemary M Gibson
Jan 3, 2007·Drug Discovery Today·William M Pardridge
May 24, 2007·Journal of Neuroscience Research·K BrännvallK Forsberg-Nilsson
Feb 6, 2008·Expert Opinion on Drug Delivery·Giovanni TosiMaria Angela Vandelli
Jan 20, 2009·Recent Patents on Drug Delivery & Formulation·Shadab A PathanFarhan J Ahmad
Feb 10, 2009·Current Topics in Medicinal Chemistry·Nunzio DenoraGiuseppe Trapani
May 1, 2009·Acta Biomaterialia·Tzu-Wei Wang, Myron Spector
Aug 12, 2009·Neurobiology of Disease·N Joan AbbottDavid J Begley
Sep 26, 2009·Seminars in Immunopathology·Britta Engelhardt, Lydia Sorokin
Feb 20, 2010·Nature Reviews. Drug Discovery·Steven M PaulAaron L Schacht
May 26, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Intakhab AlamM Akbar
Jun 22, 2010·Immunology·Sandra AmorPaul van der Valk
Nov 15, 2011·Nature Reviews. Drug Discovery·Marica GrskovicGeorge Q Daley
Nov 29, 2011·Advanced Drug Delivery Reviews·Jeffrey J Lochhead, Robert G Thorne
Jan 3, 2012·Advanced Drug Delivery Reviews·Toral PatelW Mark Saltzman
Nov 7, 2012·Journal of Biomedical Materials Research. Part a·Matthew J CaiccoMolly S Shoichet
Feb 6, 2013·ACS Chemical Neuroscience·Alison Burgess, Kullervo Hynynen
Mar 8, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Mohammad Z AlbannaHoward W T Matthew
Jun 4, 2013·Expert Opinion on Drug Discovery·Thorsten Gorba, Luciano Conti
Jun 7, 2013·Interface Focus·Xiumei WangFu-Zhai Cui
Aug 29, 2013·Advanced Drug Delivery Reviews·Jörg Kreuter
Sep 5, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roger Y TamMolly S Shoichet
Dec 12, 2013·Chemical Biology & Drug Design·Jocelyn StockwellChangiz Taghibiglou
Feb 5, 2014·Advanced Drug Delivery Reviews·Swapnil V BhujbalSimone P Niclou
May 30, 2014·International Journal of Nanomedicine·Cui-Tao LuXin-Qiao Tian
Nov 29, 2014·Stem Cells International·Stefanie RaabLeonhard Linta
Jan 7, 2015·Cold Spring Harbor Perspectives in Biology·Richard Daneman, Alexandre Prat
Mar 21, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·O van TellingenH E de Vries
Apr 14, 2015·BioMed Research International·Arijit BhowmikMrinal Kanti Ghosh
Jan 1, 2013·ISRN Biochemistry·Massimo Masserini
May 9, 2015·Advanced Materials·Ting-Chen TsengShan-hui Hsu

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Citations

Nov 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana SilvaRui Pedrosa
Mar 16, 2021·Emergent Materials·Amene Saghazadeh, Nima Rezaei
Jun 4, 2021·ACS Applied Materials & Interfaces·Min-Ah OhTaek Dong Chung
Jun 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tapan BehlSimona Bungau

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