Neurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic Interventions

Journal of Neurodegenerative Diseases
Saba SheikhSnober S Mir

Abstract

Neurodegenerative diseases are multifactorial debilitating disorders of the nervous system that affect approximately 30 millionindividuals worldwide. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis diseases are the consequence of misfolding and dysfunctional trafficking of proteins. Beside that, mitochondrial dysfunction, oxidative stress, and/or environmental factors strongly associated with age have also been implicated in causing neurodegeneration. After years of intensive research, considerable evidence has accumulated that demonstrates an important role of these factors in the etiology of common neurodegenerative diseases. Despite the extensive efforts that have attempted to define the molecular mechanisms underlying neurodegeneration, many aspects of these pathologies remain elusive. However, in order to explore the therapeutic interventions directed towards treatment of neurodegenerative diseases, neuroscientists are now fully exploiting the data obtained from studies of these basic mechanisms that have gone awry. The novelty of these mechanisms represents a challenge to the identification of viable drug targets and biomarkers for early diagnosis of the disease...Continue Reading

References

Jun 17, 1998·Journal of Neuroimmunology·T V Pedchenko, S M LeVine
May 2, 2001·The British Journal of Psychiatry : the Journal of Mental Science·C BellD Nutt
Jan 5, 2002·Journal of Bioenergetics and Biomembranes·H R McLennan, M Degli Esposti
Mar 5, 2003·American Journal of Epidemiology·Isabelle BaldiPatrick Brochard
Dec 20, 2003·Nature·Christopher M Dobson
Jun 24, 2004·The Journal of Comparative Neurology·Jodi L McBrideJeffrey H Kordower
May 10, 2005·DNA Repair·Bennett Van HoutenJanine H Santos
Aug 2, 2005·Nature Cell Biology·Amie J McClellanJudith Frydman
Mar 7, 2006·Protein and Peptide Letters·Christopher M Dobson
Jul 11, 2006·Neuro-Signals·Klaus HeeseNoriko Inoue
Mar 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew Feigin, David Eidelberg
Mar 31, 2007·Nature Reviews. Drug Discovery·David C RubinszteinDaniel J Klionsky
Apr 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·Martin OttBoris Zhivotovsky
Sep 7, 2007·Trends in Cell Biology·Ruth Scherz-Shouval, Zvulun Elazar
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Lucio G CostaAnnabella Vitalone
Feb 16, 2008·Science·William E BalchJeffery W Kelly
Mar 18, 2008·Neurosurgical Focus·Claire D ClellandColin Watts
Aug 1, 2008·Journal of Medicinal Chemistry·Morteza MalakoutikhahErnest Giralt
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Feb 14, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katalin Prokai-Tatrai, Laszlo Prokai
Jun 6, 2009·Nature Structural & Molecular Biology·F Ulrich Hartl, Manajit Hayer-Hartl
Aug 6, 2009·Annual Review of Genetics·Congcong He, Daniel J Klionsky
Aug 27, 2009·Journal of Neural Transmission·Kurt A Jellinger
Oct 16, 2009·Nature·Lennart Mucke
Nov 17, 2009·Nature Structural & Molecular Biology·Stephen TamJudith Frydman
Feb 12, 2010·Annals of the New York Academy of Sciences·Girish ModiYahya E Choonara
Apr 28, 2010·Experimental Cell Research·Haruhisa Inoue
May 7, 2010·BMJ : British Medical Journal·Jonathan Gornall
May 21, 2010·Autophagy·Daniel J KlionskySharon A Tooze
Jun 10, 2010·Nature Reviews. Molecular Cell Biology·Mikko TaipaleSusan Lindquist
Jul 24, 2010·Nature Reviews. Molecular Cell Biology·Harm H Kampinga, Elizabeth A Craig
Oct 23, 2010·Molecular Cell·Alexander BuchbergerThomas Sommer

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Citations

Sep 12, 2018·Journal of Cellular Physiology·Rasoul GodiniEsameil Ebrahimie
Jul 5, 2019·The International Journal of Neuroscience·Gaurava Srivastava, Preeti Srivastava
Oct 17, 2019·Inflammopharmacology·Diorge Jonatas MarmittMárcia Inês Goettert
Apr 17, 2020·Current Topics in Medicinal Chemistry·Aishika DattaPallab Bhattacharya
Jul 28, 2018·Oxidative Medicine and Cellular Longevity·Adaze Bijou EnogieruOkobi Eko Ekpo
Jun 14, 2020·Journal of Computer-aided Molecular Design·Shalini Thiruchittampalam, Samantha Weerasinghe
Feb 2, 2019·Neurotoxicity Research·Sachchida Nand RaiSurya Pratap Singh
Sep 10, 2020·Journal of Personalized Medicine·Chiara ArgentatiSabata Martino
Mar 5, 2016·Molecular Neurobiology·Babak EmamalizadehHossein Darvish
Dec 1, 2020·PloS One·Saeed AnwarMohammad Jakir Hosen
Oct 21, 2020·Biomedicines·Adrian Florian BălașaAlexandru Mihai Grumezescu
Jun 22, 2021·Frontiers in Molecular Biosciences·Alejandro Soto-OspinaAndrés Villegas Lanau
Nov 1, 2016·Journal of Proteome Research·Fang Liu, Michael C Fitzgerald

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Methods Mentioned

BETA
protein

Software Mentioned

MTDL

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