Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches

Brain Sciences
Rashad HussainMuhammad Shahab

Abstract

Regeneration refers to regrowth of tissue in the central nervous system. It includes generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential functions: sensory, motor, emotional and cognitive abilities. Unfortunately, regeneration within the nervous system is very slow compared to other body systems. This relative slowness is attributed to increased vulnerability to irreversible cellular insults and the loss of function due to the very long lifespan of neurons, the stretch of cells and cytoplasm over several dozens of inches throughout the body, insufficiency of the tissue-level waste removal system, and minimal neural cell proliferation/self-renewal capacity. In this context, the current review summarized the most common features of major neurodegenerative disorders; their causes and consequences and proposed novel therapeutic approaches.

References

Sep 1, 1976·Brain : a Journal of Neurology·D M BowenA N Davison
Jan 1, 1978·Cytogenetics and Cell Genetics·M A Pericak-VanceJ M Vance
May 9, 1977·Psychopharmacology·R C Petersen
Dec 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Mesulam
Dec 1, 1992·Journal of Neuroscience Research·G V Johnson, R S Jope
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·E E Baulieu, P Robel
Nov 13, 1986·The New England Journal of Medicine·W K SummersA Kling
Dec 1, 1989·Experimental Neurology·G A Higgins, E J Mufson
May 1, 1989·Trends in Pharmacological Sciences·I Izquierdo
Nov 1, 1987·Neurobiology of Aging·B T Hyman, G W Van Hoesen
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Hoyer
Feb 1, 1974·Archives of Neurology·D A Drachman, J Leavitt
Dec 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·S Lovestone, R Howard
Apr 1, 1995·Trends in Neurosciences·M A SmithG Perry
Mar 4, 1995·BMJ : British Medical Journal·N Quinn
Aug 1, 1994·American Journal of Epidemiology·A Paganini-Hill, V W Henderson
Feb 1, 1996·Current Opinion in Neurobiology·C E Henderson
Oct 1, 1996·Archives of Neurology·R N RosenbergG D Schellenberg
Feb 9, 1996·Neuroscience Letters·M TakahashiH Okada
May 21, 1998·Brain Research·W PanA J Kastin
May 29, 1999·The Journal of Biological Chemistry·D S MiddlemasX Zhu
Jun 24, 1999·The New England Journal of Medicine·J B Martin
Apr 1, 2000·Journal of Neuropathology and Experimental Neurology·E M SigurdssonB Frangione
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Oct 14, 2000·Experimental Neurology·D W HowellsG A Donnan
Jan 6, 2001·Endocrinology·D B Dubal, P M Wise

❮ Previous
Next ❯

Citations

Feb 7, 2020·Expert Opinion on Drug Delivery·Smrithi PadmakumarMansoor M Amiji
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tanja M LunićBiljana Dj Božić Nedeljković
Dec 22, 2019·International Journal of Molecular Sciences·Haena MoonHyunju Chung
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antonella SgambatoLaura Cipolla
Aug 28, 2020·Frontiers in Cellular Neuroscience·Cristina Salado-ManzanoJosep M Canals
Aug 14, 2020·Pharmaceuticals·Marzia VasarriDonatella Degl'Innocenti
Oct 20, 2020·Frontiers in Neuroscience·Raygene Martier, Pavlina Konstantinova
Nov 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana SilvaRui Pedrosa
Nov 22, 2020·International Journal of Environmental Research and Public Health·Doyeon LeeKeunhwan Kim
Jan 31, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Brian FianiErika Sarno
Dec 31, 2019·Journal of Electrical Bioimpedance·André B CunhaChristin Schuelke
May 1, 2021·International Journal of Molecular Sciences·Yiyun JinFrancesco Antonio Aprile
Oct 17, 2020·Neural Regeneration Research·Vanessa CastelliAnnamaria Cimini
May 24, 2021·Ageing Research Reviews·Hyeon-Ah Do, Kwang-Hyun Baek
Jun 3, 2021·Biology·Katsuya IuchiHisashi Hisatomi
Jun 11, 2021·Frontiers in Aging Neuroscience·María Olimpia Paz AlvarengaRafael Rodrigues Lima
Dec 10, 2020·Current Protein & Peptide Science·Debanjan Kundu, Vikash Kumar Dubey
Jan 11, 2022·Journal of Complementary & Integrative Medicine·Divya SankaramourthySudha Rani Sadras

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.