Neurodevelopment, growth, and viral load in HIV-infected infants

Brain, Behavior, and Immunity
H PollackS Oberfield

Abstract

The relation of HIV-1 infection to infant growth and neurodevelopment was studied prospectively in a cohort of 65 infants born to women at risk for HIV infection. No differences were observed at birth between infected infants (INF) and uninfected infants (SR) of HIV-infected women, and infants of uninfected women (SN) with similar socioeconomic background and exposure to drugs. However, postnatal linear growth and cognitive-motor development of INF infants were impaired when compared to SR and SN infants. Declines in linear growth were observed within the first 6 months of life, whereas delays in neurodevelopment were first appreciated at 12 months. In INF infants, decreased linear growth was positively correlated with developmental delay. Moreover, growth and development were both correlated with HIV viral load. INF infants with high plasma HIV RNA copies (> 5 x 10(5)/ ml) at 6 months of life were more likely to exhibit severe growth and developmental delay than infants with a lower viral burden. The implications of these findings with respect to the mechanism of action of HIV-related growth and neurodevelopmental impairments are discussed.

Citations

Jun 13, 2009·Nutrition Reviews·Sheila IsanakaWafaie W Fawzi
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·M HornigW I Lipkin
Feb 7, 2003·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marisha E Meleski, Elizabeth G Damato
Oct 24, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sanneke KoekkoekSibyl P M Geelen
Aug 22, 2009·Psychology, Health & Medicine·Lorraine SherrRebecca Varrall
Dec 13, 2006·Brain, Behavior, and Immunity·Robert H BonneauJohn F Sheridan
Dec 2, 2006·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Annelies Van RieKevin Robertson
May 9, 2014·Reviews in Medical Virology·Claudia S CrowellWilliam J Muller
Jun 3, 2009·Developmental Medicine and Child Neurology·Amina AbubakarFons J R van de Vijver
Apr 5, 2014·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Renee Smith, Megan Wilkins
Aug 25, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Walter J PsoterFrank Catalanotto
Sep 13, 2001·Mental Retardation and Developmental Disabilities Research Reviews·W Mitchell
May 15, 1998·Acta Paediatrica Japonica; Overseas Edition·L G Epstein
Aug 22, 2014·The Pediatric Infectious Disease Journal·Sarah Benki-NugentGrace John-Stewart
May 28, 2011·Journal of Child Neurology·Rajeshree GovenderJo M Wilmshurst
Dec 15, 2017·AIDS Research and Human Retroviruses·Angela M AmedeeKristina De Paris
Mar 6, 2010·Pediatric Surgery International·M ArnoldG F Kirsten
Apr 21, 2011·Maternal and Child Health Journal·Hamisu M SalihuAlfred K Mbah
Jul 26, 2011·Indian Journal of Pediatrics·Anju SethAshok Dutta
Dec 4, 2019·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Thomas StruyfAnnelies Van Rie
Apr 6, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Reshma SirajeeMichael T Hawkes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.