Neurodevelopment of 24 children born in Brazil with congenital Zika syndrome in 2015: a case series study

BMJ Open
Lucas V AlvesJoao G Alves

Abstract

To describe the neurodevelopment of children with congenital Zika syndrome during the second year of life. Case series study. Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Pernambuco, Brazil. 24 children with congenital Zika syndrome born with microcephaly during the Zika outbreak in Brazil in 2015 and followed up at the IMIP during their second year of life. Denver Developmental Screening Test II, head circumference and clinical neurological examination. All children presented neurodevelopmental delay: for an average chronological age of 19.9 months, language was equivalent to that of age 2.1 months, gross motor 2.7 months, fine motor/adaptive 3.1 months and personal/social 3.4 months. Head circumference remained below the third percentile for age and gender, and growth rate up to the second year of life was 10.3 cm (expected growth 13 cm). Muscle tone was increased in 23 (95.5%) of 24 children, musculotendinous reflexes were increased in the whole sample and clonus was present in 18 (77.3%) of 24 children. All children except one had epilepsy. Children born with microcephaly associated with congenital Zika virus have a significant neurodevelopmental delay.

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Citations

Apr 22, 2019·Journal of Tropical Pediatrics·Renata Artimos de Oliveira ViannaClaudete Aparecida Araújo Cardoso
Mar 29, 2019·Journal of Developmental and Behavioral Pediatrics : JDBP·Eliza Gordon-Lipkin, Georgina Peacock
Nov 14, 2019·Journal of Child Neurology·Alessandra Lemos de CarvalhoRita Lucena
Sep 16, 2020·Developmental Medicine and Child Neurology·Alessandra CarvalhoRita Lucena
Sep 29, 2020·Journal of Tropical Pediatrics·Miguel García-BoyanoGreta Miño-León
Oct 12, 2020·BMC Pediatrics·Paula Fabiana Sobral da SilvaDemócrito de Barros Miranda-Filho
Nov 26, 2020·Viruses·Marília Rosa Abtibol-BernardinoMaria das Graças Costa Alecrim
Aug 28, 2020·International Journal of Pediatric Otorhinolaryngology·Barbara Cristina da Silva RosaDoris Ruthy Lewis
Jan 31, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth M StringerFilemon Bucardo
Oct 29, 2020·Neuropediatrics·Eliana Harumi Morioka TakahasiAntônio Augusto Moura da Silva
Dec 1, 2020·PLoS Neglected Tropical Diseases·Karen BlackmonA Desiree LaBeaud
Dec 15, 2020·Epilepsy & Behavior Reports·Piumi JayatilakeKaren Blackmon
Mar 30, 2021·Epilepsia·César Quadros MaiaJaqueline Maria Siqueira Ferreira
Jul 3, 2021·International Journal of Environmental Research and Public Health·Liora GonikJaqueline da Silva Frônio
Jul 29, 2021·Journal of Child Neurology·Lucas Victor AlvesJoao Guilherme Bezerra Alves
Mar 14, 2020·Acta Tropica·Renata Artimos de Oliveira ViannaClaudete Aparecida Araújo Cardoso
Aug 29, 2021·Viruses·Paula Fabiana Sobral da Silva On Behalf Of The Microcephaly Epidemic Research Group Merg
Oct 2, 2021·European Journal of Pediatrics·Carla Trevisan M RibeiroMarcos Pone

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