Neurodevelopment of HIV-exposed uninfected children in Cape Town, South Africa

PloS One
Hlengiwe P MadlalaMarie-Louise Newell

Abstract

Evidence shows that antiretroviral (ART) exposure is associated with neurodevelopmental delays in human immunodeficiency virus (HIV)-exposed uninfected (HEU) children. However, there are few insights into modifiable maternal and child factors that may play a role in improving neurodevelopment in HEU children. We used a parent-centric neurodevelopment tool, Ages & Stages Questionnaire (ASQ) to examined neurodevelopment in HEU children at 12-24 months of age, and associations with maternal and child factors. 505 HIV-infected women (initiated ART pre- or during pregnancy) with live singleton births attending primary health care were enrolled; 355 of their HEU children were assessed for neurodevelopment (gross motor, fine motor, communication, problem solving and personal-social domains) at 12-24 months using age-specific ASQ administered by a trained fieldworker. Associations with maternal and child factors were examined using logistic regression models. Among mothers (median age 30 years, IQR, 26-34), 52% initiated ART during pregnancy; the median CD4 count was 436 cells/μl (IQR, 305-604). Most delayed neurodevelopment in HEU children was in gross (9%) and fine motor (5%) functions. In adjusted models, maternal socio-economic sta...Continue Reading

References

Nov 30, 2004·Seminars in Perinatology·Claudette BardinApostolos Papageorgiou
Dec 14, 2004·BMJ : British Medical Journal·Michael ColvinPeter W Fowlie
May 17, 2008·Acta Paediatrica·Christine Bonnier
Mar 2, 2010·Hormone Research in Pædiatrics·H M A de BieH A Delemarre-van de Waal
Feb 12, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·B J WoodwardK L Watterberg
Apr 22, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Priscila CaçolaAna Carolina T Batistela
Feb 4, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T ArcangeliA Bhide
May 1, 2013·Pediatrics·Luisa SchonhautMiguel Cordero
Sep 27, 2013·The Pediatric Infectious Disease Journal·Mabel L RiceUNKNOWN Pediatric HIVAIDS Cohort Study (PHACS)
Sep 28, 2013·Brazilian Journal of Physical Therapy·Teresa C B FreitasDenise C C Santos
Apr 2, 2014·Nutrition Reviews·Elizabeth L Prado, Kathryn G Dewey
Nov 21, 2014·The American Journal of Clinical Nutrition·Kirsten A BorkIsabelle de Vincenzi
Aug 13, 2015·The Journal of Infectious Diseases·Nan LiWafaie Fawzi
Oct 2, 2015·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Kristjana H ÁsbjörnsdóttirGrace John-Stewart
Jun 1, 2016·Frontiers in Immunology·Russell B Van DykeGeorge R Seage
Oct 7, 2016·Child: Care, Health and Development·C HsiaoM Mabaso
Sep 16, 2017·Pediatrics·Sumona ChaudhuryShahin Lockman
Nov 14, 2017·Tropical Medicine & International Health : TM & IH·Priscilla E SpringerMariana Kruger
Nov 24, 2017·International Journal for Equity in Health·Christopher James PlayfordLee Williamson
Jan 28, 2018·Pediatrics·Megan S McHenryRachel C Vreeman
Jun 9, 2018·The Lancet Global Health·Lynne M Mofenson
Apr 16, 2019·The Pediatric Infectious Disease Journal·Adam R CassidyShahin Lockman
Sep 14, 2019·The Lancet Child & Adolescent Health·Catherine J WedderburnKirsten A Donald
Oct 30, 2019·Open Forum Infectious Diseases·Maria L AlcaideDeborah L Jones
Dec 4, 2019·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Thomas StruyfAnnelies Van Rie

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Methods Mentioned

BETA
SGA

Software Mentioned

Comm
PerSocial
ASQ
STATA
ProbSolv

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