Neurodevelopmental animal models of schizophrenia: role in novel drug discovery and development.

Clinical Schizophrenia & Related Psychoses
Christina Wilson, Alvin V Terry

Abstract

Schizophrenia is a devastating mental illness that is associated with a lifetime of disability. For patients to successfully function in society, the amelioration of disease symptoms is imperative. The recently published results of two large antipsychotic clinical trials (e.g., CATIE, CUtLASS) clearly exemplified the limitations of currently available treatment options for schizophrenia, and further highlighted the critical need for novel drug discovery and development in this field. One of the biggest challenges in schizophrenia-related drug discovery is to find an appropriate animal model of the illness so that novel hypotheses can be tested at the basic science level. A number of pharmacological, genetic, and neurodevelopmental models have been introduced; however, none of these models has been rigorously evaluated for translational relevance or to satisfy requirements of "face," "construct" and "predictive" validity. Given the apparent polygenic nature of schizophrenia and the limited translational significance of pharmacological models, neurodevelopmental models may offer the best chance of success. The purpose of this review is to provide a general overview of the various neurodevelopmental models of schizophrenia that ha...Continue Reading

References

Jan 1, 1992·Schizophrenia Bulletin·R M MurrayS W Lewis
Aug 1, 1991·Genetical Research·R T SwankE K Novak
Feb 1, 1988·Archives of General Psychiatry·S A MednickD Bonett
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
May 1, 1993·Journal of Clinical Psychology·S N BrixeyL F Parmelee
Mar 1, 1993·Archives of General Psychiatry·F E Bloom
May 20, 1998·Schizophrenia Research·B A EllenbroekA R Cools
Aug 26, 1998·Schizophrenia Research·J van Os, M Marcelis
Aug 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·J van Os, J P Selten
Feb 17, 2000·Brain Research. Developmental Brain Research·M V PletnikovT H Moran
Mar 17, 2000·Brain Research. Brain Research Reviews·T F McNeilB Ismail
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Jun 28, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B A Ellenbroek, A R Cools
Aug 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K Lipska, D R Weinberger
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·V LemaireD N Abrous
Jan 6, 2001·Neuron·D A Lewis, J A Lieberman
Jan 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·José BorrellCarmen Guaza
Jun 8, 2002·Annual Review of Neuroscience·David A Lewis, Pat Levitt
Jun 14, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gwenaëlle Le Pen, Jean-Luc Moreau
Dec 13, 2002·American Journal of Human Genetics·Hreinn StefanssonDavid St Clair
Mar 22, 2003·Experimental Cell Research·Douglas L Falls
May 20, 2003·Neurotoxicity Research·Barbara K. Lipska, Daniel R. Weinberger
Jul 31, 2003·Molecular Psychiatry·J X TangL He
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mark A Geyer, Bart Ellenbroek
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shitij Kapur, David Mamo

❮ Previous
Next ❯

Citations

Sep 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dennis R Grayson, Alessandro Guidotti
Mar 12, 2015·International Journal of Molecular Sciences·Hyman M Schipper, Wei Song
Jan 8, 2016·Behavioural Brain Research·Gonzalo FloresAlfonso Diaz
Feb 9, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Clarissa TrzesniakJosé Alexandre S Crippa
Dec 18, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Christina A Wilson, James I Koenig
Jan 5, 2013·Pharmacology, Biochemistry, and Behavior·Christina A Wilson, Alvin V Terry
Mar 31, 2015·Neuroscience Bulletin·Ping MaoYuan-Ye Ma
Jun 9, 2016·Journal of Psychiatric Research·Marc Fakhoury
Mar 28, 2018·Translational Psychiatry·Sarine S Janetsian-FritzChristopher C Lapish
Jan 25, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ayda TavitianHyman M Schipper
Jul 20, 2019·Reviews in the Neurosciences·Hans-Gert BernsteinJohann Steiner
Mar 23, 2018·Acta Pharmacologica Sinica·Meng-Yi Xu, Albert H C Wong
May 11, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Ian R WinshipJohn G Howland
Dec 21, 2019·Behavioural Pharmacology·Pushparaj GawaiRajesh R Ugale
Nov 13, 2020·Frontiers in Pharmacology·Dennis KätzelDavid M Bannerman
Feb 23, 2017·Neuroscience and Biobehavioral Reviews·Marc Fakhoury
Jun 6, 2021·Psychopharmacology·Thiago Garcia VargaTatiana Rosado Rosenstock
Aug 8, 2021·International Journal of Molecular Sciences·Soon-Ae KimEun-Hye Jang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here