PMID: 9554540Apr 29, 1998Paper

Neurodevelopmental anomalies in children with neuroblastoma

Cancer
J Blatt, R L Hamilton

Abstract

Case reports have associated neuroblastoma, a cancer derived from the embryonal neural crest, with aganglionosis coli and neurofibromatosis type I. The aim of the current study was to test the hypothesis that neuroblastoma is part of a global defect in neurodevelopment. Neuropathologic findings from autopsies of children who died of neuroblastoma during the period 1980-1995 at the Children's Hospital of Pittsburgh were reviewed for macroscopic and microscopic abnormalities. As controls, autopsies of children who had died of other primary extracranial cancers over the same time period also were studied. Medical records of neuroblastoma patients for whom autopsies were available were reviewed for clinical evidence of preexisting nonmalignant neurologic disease. Of 145 children diagnosed with neuroblastoma, 49 had died, and autopsies not restricting examination of the brain had been performed on 13. Macroscopic anatomic abnormalities (a small cerebellum and the absence of the corpus callosum) were noted in one patient who was known to have been mentally retarded without having a defined syndrome. Microscopic abnormalities of cytoarchitecture were noted in that patient as well as 3 of the 12 other patients (focal cortical dysplasia...Continue Reading

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Citations

Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Arnold C PaulinoJohn M Buatti
Oct 8, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·John A OzolekCsaba Galambos
Jan 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Evelyn S HanemaaijerHans Clevers

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