Neurodevelopmental disorders-the history and future of a diagnostic concept
.

Dialogues in Clinical Neuroscience
Deborah J Morris-Rosendahl, Marc-Antoine Crocq

Abstract

This article describes the history of the diagnostic class of neurodevelopmental disorders (NDDs) up to DSM-5. We further analyze how the development of genetics will transform the classification and diagnosis of NDDs. In DSM-5, NDDs include intellectual disability (ID), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). Physicians in German-, French- and English-speaking countries (eg, Weikard, Georget, Esquirol, Down, Asperger, and Kanner) contributed to the phenomenological definitions of these disorders throughout the 18th and 20th centuries. These diagnostic categories show considerable comorbidity and phenotypic overlap. NDDs are one of the chapters of psychiatric nosology most likely to benefit from the approach advocated by the National Institute of Mental Health's Research Domain Criteria project. Genetic research supports the hypothesis that ID, ASD, ADHD, schizophrenia, and bipolar disorder lie on a neurodevelopmental continuum. The identification of recurrently observed copy number variants and disruptive gene variants in ASD (eg, CDH8, 16p11.2, SCN2A) led to the adoption of the genotype-first approach to characterize individuals at the etiological level.
.

Citations

Feb 14, 2021·International Journal of Environmental Research and Public Health·Leonardo ZoccanteMarco Colizzi
Jan 22, 2021·Neuron·Sharan PaulStefan M Pulst
Feb 23, 2021·Human Immunology·Sukanta Jash, Surendra Sharma
May 9, 2021·Neurochemistry International·Leora D'SouzaBhavana Muralidharan
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jieon LeeHyunah Choo
Jun 26, 2021·The Journal of Clinical Endocrinology and Metabolism·Shengxin LiuAgnieszka Butwicka
Jul 10, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Júlio Santos-TerraCarmem Gottfried
Aug 11, 2021·European Archives of Psychiatry and Clinical Neuroscience·Jasmina MalletUNKNOWN FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group
Aug 12, 2021·Developmental Medicine and Child Neurology·Eva CloetMark Leys
Aug 21, 2021·Frontiers in Cell and Developmental Biology·Nicole A LynnJorge Z Torres

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.