Neurodevelopmental MACPFs: The vertebrate astrotactins and BRINPs

Seminars in Cell & Developmental Biology
Susan R BerkowiczPhillip I Bird

Abstract

Astrotactins (ASTNs) and Bone morphogenetic protein/retinoic acid inducible neural-specific proteins (BRINPs) are two groups of Membrane Attack Complex/Perforin (MACPF) superfamily proteins that show overlapping expression in the developing and mature vertebrate nervous system. ASTN(1-2) and BRINP(1-3) genes are found at conserved loci in humans that have been implicated in neurodevelopmental disorders (NDDs). Here we review the tissue distribution and cellular localization of these proteins, and discuss recent studies that provide insight into their structure and interactions. We highlight the genetic relationships and co-expression of Brinps and Astns; and review recent knock-out mouse phenotypes that indicate a possible overlap in protein function between ASTNs and BRINPs.

References

Nov 21, 2014·Journal of Neural Transmission·Ke-Sheng WangChun Xu

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Citations

Jun 7, 2019·Chembiochem : a European Journal of Chemical Biology·Hisaaki HiroseHiroaki Suga
Oct 21, 2020·BMC Evolutionary Biology·Miguel Araujo-Voces, Víctor Quesada
Nov 13, 2020·Frontiers in Immunology·Charles Bayly-JonesMichelle A Dunstone
Nov 9, 2021·Biochemical Society Transactions·Joshua T Benton, Charles Bayly-Jones
Aug 20, 2021·Psychiatric Genetics·Alessia BauleoElena Falcone

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