Neurodevelopmental outcome in congenital diaphragmatic hernia survivors: role of ventilatory time

Journal of Pediatric Surgery
F BevilacquaL Aite

Abstract

Neurodevelopmental impairment is one of the most significant morbidities among CDH survivors. Assess correlation between ventilatory time (VT) and short-term neurodevelopmental outcome in congenital diaphragmatic hernia (CDH) survivors. A prospective longitudinal study was conducted between 2008 and 2012. Assessment of mental and motor development was performed at 6 and 12months by Bayley Scales of Infant and Toddler Development - 3rd Edition (BSID-III). ROC curve analysis was used. Forty-two subjects were included in the study. There was a significant inverse correlation between neurodevelopment at 6 and 12months and VT during first admission (p<0.0001). VT predicting the risk of moderate (BSID-III <85) and severe (BSID-III <70) delay was 13 and 28days, respectively (area under the curve - delay <85: 6months mental 0.943 and motor 0.992; 12months mental 0.877 and motor 0.925; delay <70: 6months mental 0.934 and motor 0.943; 12months mental 0.906 and motor 0.975; p<0.0001). VT should be considered an important marker to identify subjects at risk for short-term neurodevelopmental delay in CDH survivors. Early follow-up intervention therapy should be activated in every baby with a history exceeding 13days of VT.

References

Apr 19, 2000·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·N H BoumanF W Hazebroek
May 4, 2005·Journal of Pediatric Surgery·Raul A CortesKerilyn K Nobuhara
Jun 24, 2005·The Journal of Pediatrics·Michele C WalshUNKNOWN National Institutes of Child Health and Human Development Neonatal Research Network
Apr 28, 2007·Seminars in Pediatric Surgery·Pietro Bagolan, Francesco Morini
Mar 4, 2008·Pediatrics·Kevin P LallyWilliam Engle
May 24, 2008·Anesthesia and Analgesia·Andreas W Loepke, Sulpicio G Soriano
Dec 22, 2010·British Journal of Anaesthesia·L Sun
Jun 7, 2011·Early Human Development·Enrico Danzer, Holly L Hedrick
Feb 5, 2013·The Journal of Pediatrics·Julia WynnMarc S Arkovitz
Feb 16, 2013·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Christopher McPherson
May 11, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·E DanzerH L Hedrick
Oct 8, 2013·Journal of Pediatric Surgery·Julia WynnChristiana Farkouh

❮ Previous
Next ❯

Citations

Mar 19, 2015·Journal of Pediatric Surgery·Francesca BevilacquaLucia Aite
Aug 16, 2016·Journal of Pediatric Surgery·Katarina BojanićRuža Grizelj
Nov 4, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Bevilacqua FrancescaAite Lucia
Feb 19, 2021·Prenatal Diagnosis·Francesca M RussoJan Deprest
May 1, 2021·Brain Sciences·Martina LucignaniAntonio Napolitano
Jul 4, 2021·Prenatal Diagnosis·Lennart Van der VeekenJan Deprest

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association
Barbara J JacksonCarol McMorris
Journal of Perinatology : Official Journal of the California Perinatal Association
Enrico DanzerHolly L Hedrick
Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association
Alison LaneJill Heathcock
© 2022 Meta ULC. All rights reserved