Abstract
Necrotizing enterocolitis (NEC), a gastrointestinal emergency predominantly affecting premature infants, is associated with increased risk for poor neurodevelopmental outcomes. NEC often strikes during a period of rapid and dynamic neurologic development when the brain is particularly vulnerable to insults and nutrient deficits. The pathogenesis of neurodevelopmental impairment following NEC is likely multifactorial, with both nutritional and non-nutritional factors at play. Follow-up testing that ensures early detection and intervention for impairments is crucial to optimize neurodevelopmental outcomes following NEC. A multifaceted approach to follow-up after NEC is necessary, with close monitoring of growth, serial developmental assessments, neurologic examinations, hearing and vision testing and neuroimaging. Further research is needed to understand the pathogenesis of neurodevelopmental impairment following NEC, to identify more targeted follow-up tests, and to discover interventions aimed at optimizing neurodevelopmental outcomes following NEC.
Citations
Dec 8, 2019·Experimental Biology and Medicine·Alissa L MeisterR Alberto Travagli
Oct 28, 2019·Journal of Pediatric Gastroenterology and Nutrition·Riikka J GunnarLaura Merras-Salmio
Aug 9, 2020·Disease Models & Mechanisms·Mark L KovlerDavid J Hackam
Dec 6, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Andreea MateiAugusto Zani
Sep 3, 2020·NeoReviews·Jennifer Fundora, Susan W Aucott
Nov 29, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Osnat ZmoraRon Beloosesky
Mar 8, 2021·Journal of Neuroinflammation·Fangxinxing ZhuJin Wu
Oct 16, 2020·The Cochrane Database of Systematic Reviews·Sahar SharifWilliam McGuire
May 11, 2021·Frontiers in Immunology·Maame Efua S Sampah, David J Hackam
Jun 16, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Anitha MadayiPratibha Keshav Agarwal
Dec 18, 2020·The Journal of Infectious Diseases·Robert ThänertPhillip I Tarr
Aug 25, 2021·The Cochrane Database of Systematic Reviews·Sam J OddieWilliam McGuire
Aug 28, 2021·Nutrients·Miheret YitayewKaren D Hendricks-Muñoz
Sep 4, 2021·JAMA Network Open·Ravi M PatelCassandra D Josephson
Sep 2, 2021·Clinical & Translational Immunology·Lakshanie C WickramasingheMargaret L Hibbs
Jul 1, 2020·American Journal of Perinatology·Nilima JawaleUNKNOWN for Maimonides Neonatal Group
Apr 12, 2019·Neonatology·Verena Walsh, William McGuire
Apr 12, 2019·Neonatology·Hendrik J NiemarktBoris W Kramer
Jan 21, 2022·The Cochrane Database of Systematic Reviews·Lauren YoungWilliam McGuire
Apr 28, 2021·Current Pediatric Reviews·Serafina PerroneSusanna Esposito