PMID: 15379298Sep 24, 2004Paper

Neurodevelopmental outcomes of children born to mothers with epilepsy

Cleveland Clinic Journal of Medicine
Kimford J Meador, Mary L Zupanc

Abstract

Most children born to women with epilepsy are normal, but there is an increased risk of abnormal functional neurodevelopment in these children. Although there are many contributing factors, antiepileptic drugs (AEDs) may play a role. Most women with epilepsy must take AEDs during pregnancy because the potential for injury from seizures to both mother and fetus is a greater risk. AEDs are also used to treat other disorders, including depression and pain. Thus, an understanding of the effects of AEDs on the unborn child is relevant to physicians who treat nonepileptic mothers as well. This review discusses animal and human studies of the neurodevelopmental effects of AEDs and briefly reviews the possible mechanisms underlying these effects. Flaws in the methodology of some studies of these effects require that the results be interpreted cautiously and highlight the need for well-designed studies to explore this issue further.

Citations

Jul 11, 2006·Current Neurology and Neuroscience Reports·Gholam K Motamedi, Kimford J Meador
Jul 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Sowbhagya Lakshmi, Kulkarni Sunanda
Oct 12, 2004·Neurologic Clinics·Page B Pennell
Sep 4, 2015·Indian Journal of Psychiatry·Sonia Parial
Mar 22, 2014·The Cochrane Database of Systematic Reviews·Janine B WinterbottomGus A Baker
Mar 1, 2015·Future Neurology·Swapna Putta, Page B Pennell
Jan 1, 2010·Expert Review of Clinical Pharmacology·Kai Eriksson, Reetta Kälviäinen

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