PMID: 8939180Nov 1, 1996Paper

Neuroeffector mechanisms: the interface between inflammation and neuronal responses

The Journal of Allergy and Clinical Immunology
P J Barnes

Abstract

There is a complex relation between inflammation and neural control of the airways. Cholinergic neurotransmission may be enhanced by inflammatory mediators; cholinergic nerves are the dominant neural pathway for bronchoconstriction in humans. Anticholinergic drugs are more effective in acute severe asthma than in chronic asthma, suggesting that cholinergic mechanisms may be important in exacerbations. Several possible abnormalities in adrenergic control in asthma have been proposed and may be caused by the inflammatory process. Adrenergic nerves do not have direct control of airway smooth muscle but may influence bronchomotor tone in several ways, such as adrenergic neural control of the bronchial vasculature or a secondary effect on cholinergic neurotransmission. Nonadrenergic noncholinergic (NANC) mechanisms mediate both bronchoconstriction and bronchodilation, and a defect in NANC bronchodilatation has been suggested to operate in severe asthma. Relatively little is known about the properties of airway sensory (afferent) nerves in human beings. They are thought to be involved in symptoms of cough and chest tightness, and the threshold for their activation is lowered in conditions of chronic inflammation. In addition, retrogr...Continue Reading

Citations

Feb 13, 2001·European Journal of Pharmacology·I Greczko, T Tyrakowski
Jan 15, 2002·Chest Surgery Clinics of North America·G Tougas, M Banemai
May 22, 2002·Current Opinion in Pharmacology·Maria G Belvisi
May 22, 2002·Current Opinion in Pharmacology·Armin BraunHarald Renz
Sep 14, 2002·Journal of Toxicology and Environmental Health. Part a·Kaoru HamadaLester Kobzik
Jun 29, 2006·International Archives of Allergy and Immunology·Shigemi YoshiharaOsamu Arisaka
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·J C VirchowA Braun
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·C KotaruE R McFadden
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Günter PäthHarald Renz
Aug 13, 2004·American Journal of Respiratory and Critical Care Medicine·Shigemi YoshiharaOsamu Arisaka
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·A BraunH Renz
Jun 30, 2015·Neuron·Sébastien TalbotClifford J Woolf
Jun 7, 2005·British Journal of Pharmacology·Marcello TrevisaniSelena Harrison
Jul 9, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Tsu-Nai WangYing-Chin Ko
Mar 19, 1999·Brain, Behavior, and Immunity·V J DjurićM Steiner
Jul 18, 2014·NPJ Primary Care Respiratory Medicine·David PriceMiguel Román-Rodríguez
Aug 30, 2016·Inhalation Toxicology·Robyn L Prueitt, Julie E Goodman
May 26, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Andrew BushSejal Saglani
May 8, 2018·Indian Journal of Pediatrics·Anirban Maitra
Dec 12, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O NogaG Kunkel
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A BraunH Renz
Aug 17, 2005·International Archives of Allergy and Immunology·Shigemi YoshiharaOsamu Arisaka
Nov 10, 1998·European Journal of Immunology·A BraunH Renz
Jul 22, 2019·European Journal of Immunology·Lilian BassoNicolas Gaudenzio
Dec 8, 2004·The Journal of Pharmacology and Experimental Therapeutics·Carla F Franco-PenteadoEdson Antunes
Feb 11, 2014·Current Protocols in Pharmacology·Eric DubuisMaria G Belvisi
Nov 9, 2002·Autonomic & Autacoid Pharmacology·K M Ellis, J R Fozard
May 6, 2004·Current Opinion in Allergy and Clinical Immunology·Inga HansenKarl Hörmann
Nov 8, 2016·Current Opinion in Pulmonary Medicine·Maria D'AmatoGennaro D'Amato
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Sep 3, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yoshihiko ChibaSeiji Shioda

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