Neuroendocrine aspects of catamenial epilepsy.

Hormones and Behavior
D S Reddy

Abstract

This review describes the neuroendocrinological aspects of catamenial epilepsy, a menstrual cycle-related seizure disorder in women with epilepsy. Catamenial epilepsy is a multifaceted neuroendocrine condition in which seizures are clustered around specific points in the menstrual cycle, most often around perimenstrual or periovulatory period. Three types of catamenial seizures (perimenstrual, periovulatory and inadequate luteal) have been identified. The molecular pathophysiology of catamenial epilepsy remains unclear. Cyclical changes in the circulating levels of estrogens and progesterone (P) play a central role in the development of catamenial epilepsy. Endogenous neurosteroids such as allopregnanolone (AP) and allotetrahydrodeoxycorticosterone (THDOC) that modulate seizure susceptibility could play a critical role in catamenial epilepsy. In addition, plasticity in GABA-A receptor subunits could play a role in the enhanced seizure susceptibility in catamenial epilepsy. P-derived neurosteroids such as AP and THDOC potentiate synaptic GABA-A receptor function and also activate extrasynaptic GABA-A receptors in the hippocampus and thus may represent endogenous regulators of catamenial seizure susceptibility. Experimental studi...Continue Reading

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Citations

Jun 1, 2014·Frontiers in Neuroendocrinology·Ashley M Fortress, Karyn M Frick
Jun 25, 2014·Neurobiology of Disease·Doodipala Samba Reddy
Jun 15, 2013·Journal of Neuroendocrinology·G BiaginiS Meletti
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May 6, 2016·Frontiers in Cellular Neuroscience·Doodipala Samba Reddy
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May 14, 2016·Epilepsy & Behavior : E&B·Rachel R FabrisGregory D Cascino
Jul 18, 2016·Pharmacology, Biochemistry, and Behavior·Doodipala Samba Reddy
Mar 29, 2019·Continuum : Lifelong Learning in Neurology·Mona Sazgar
Nov 17, 2017·The Journal of Pharmacology and Experimental Therapeutics·Shu-Hui Chuang, Doodipala Samba Reddy
May 15, 2013·The Journal of Pharmacology and Experimental Therapeutics·Xin WuDoodipala Samba Reddy
Nov 22, 2016·Journal of Neuroscience Research·Doodipala Samba Reddy
Aug 4, 2020·Acta neurologica Belgica·Megha Gautam, Ganesh Thapa
Jul 18, 2019·Frontiers in Neurology·Dominik KobylarekWojciech Kozubski
Jan 10, 2021·Neuroscience Letters·Jaideep Kapur, Suchitra Joshi
Mar 11, 2017·Pharmacology & Therapeutics·Iyan Younus, Doodipala Samba Reddy
Oct 9, 2021·Neurochemical Research·Priyanka PahwaRajesh Kumar Goel

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