PMID: 2492202Jan 1, 1989Paper

Neuroendocrine aspects of primary endogenous depression. V. Serum prolactin measures in patients and matched control subjects

Biological Psychiatry
R T RubinD J Martin

Abstract

To ascertain the extent of dysregulation of prolactin (PRL) secretion in endogenous depression, we determined nocturnal serum PRL concentrations and PRL responses to thyrotropin-releasing hormone (TRH), gonadotropin-releasing hormone (LHRH), and dexamethasone administration in 40 Research Diagnostic Criteria (RDC) primary, definite endogenous depressives and 40 individually matched normal control subjects. Compared to their matched controls, the patients showed no difference in basal nocturnal PRL concentrations, a marginally significant 20%-25% increase in the PRL response to TRH, and no differences in post-LHRH or postdexamethasone PRL concentrations. In the patients, there was a weak, negative correlation between age and PRL (r = -0.30), but none of the other subject characteristics or specific dimensions of depressive symptomatology were significantly related to the PRL measures. The PRL measures also were unrelated to pre- and postdexamethasone cortisol concentrations and to the thyrotropin (TSH) responses to TRH in both groups of subjects. In contrast to the previously reported hypothalamo-pituitary-adrenal cortical and thyroid axis abnormalities in these patients, our findings suggest that PRL secretion was relatively no...Continue Reading

References

Apr 1, 1978·Psychoneuroendocrinology·A E Boyd, S Reichlin
Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·S J JuddS S Yen
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G CopinschiC Robyn
Oct 1, 1979·Archives of General Psychiatry·U HalbreichM Ben-David
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·K MaedaH Imura
Jan 1, 1985·Endocrine Reviews·N Ben-Jonathan
Jan 1, 1986·Journal of Psychiatric Research·A P ZisN E Lohr
Jan 1, 1987·Biological Psychiatry·H M van PraagR Kahn
Aug 1, 1987·Acta Psychiatrica Scandinavica·R RupprechtW Schwarz
Oct 1, 1985·Psychiatry Research·O M WolkowitzS M Paul
Jan 1, 1985·Hormone Research·M J Reymond, J C Porter
Apr 1, 1985·Psychiatry Research·B F KjellmanL Wetterberg
Mar 1, 1985·The Journal of Urology·W E Farnsworth
Oct 1, 1985·Psychological Reports·R A Steer, A T Beck
Sep 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·F M MaiD Giles
Dec 1, 1985·Psychological Reports·K VredenburgG L Flett
Jun 1, 1973·The Journal of Clinical Endocrinology and Metabolism·L S JacobsW H Daughaday
Jul 1, 1972·The British Journal of Psychiatry : the Journal of Mental Science·M W Carney, B F Sheffield
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Nov 1, 1983·Clinics in Endocrinology and Metabolism·A Grossman
Apr 1, 1984·Psychiatry Research·A G RobertsonH Y Meltzer
May 1, 1983·Archives of General Psychiatry·J D AmsterdamK Rickels
Jun 1, 1983·The American Journal of Psychiatry·P T LoosenA J Prange
Sep 1, 1984·Acta Psychiatrica Scandinavica·H E KleinM Schmauss
Apr 1, 1983·Psychiatry Research·M R Cohen
Dec 1, 1980·Psychiatry Research·P LinkowskiJ Mendlewicz
Jan 1, 1982·The American Journal of Psychiatry·A WinokurD Brunswick
Feb 1, 1982·Psychiatry Research·S D TargumS M Byrnes
Dec 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A BarbarinoC Farabegoli
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·E GrofP Grof

❮ Previous
Next ❯

Citations

Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·R T Rubin
Mar 5, 2005·European Archives of Psychiatry and Clinical Neuroscience·Cornelius SchüleRainer Rupprecht
Aug 1, 1991·Biological Psychiatry·I M Anderson, P J Cowen
Apr 1, 1994·Biological Psychiatry·G S WatermanN D Ryan
Jan 1, 1991·Journal of Psychiatric Research·M MaesP Cosyns
Oct 1, 1991·The Journal of General Psychology·J B Murray
Mar 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·G L HannaD P Cantwell
Sep 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·M D De BellisN D Ryan
Aug 25, 1999·Biological Psychiatry·A HardanN D Ryan
Feb 8, 2005·Psychoneuroendocrinology·Cornelius SchüleRainer Rupprecht
Feb 3, 2005·Molecular Psychiatry·A Marques-DeakE Sternberg
Mar 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·I M AndersonP J Cowen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.