Neuroendocrine cells associated with neuroendocrine carcinoma of the breast: nature and significance

Journal of Clinical Pathology
T KawasakiR Katoh

Abstract

The developmental mechanisms of breast neuroendocrine carcinoma (B-NEC) have not been sufficiently analysed and are not well understood. To investigate NE cells in the background tissues surrounding B-NECs. Three cases (four breasts) having many NE cells in the background tissues of multifocal B-NECs were identified at the University of Yamanashi Hospital and St Luke's International Hospital, Japan. These patients were, respectively, 28-, 31- and 38-year-old women with no familial history of NE tumour. The totally-resected breasts were serially studied by immunohistochemistry for specific NE markers (chromogranin A/synaptophysin) and the morphologies and/or localisation of NE cells were investigated. Immunohistochemical examination showed extensively-distributed NE cells in the background mammary ducts/lobules of the NECs in all breasts. These NE cells were classifiable into three emerging patterns: isolated/scattered, clustered and circumferential. Their distributions were intermingled and were not clearly related to B-NEC foci. NE cells were morphologically polygonal, oval or columnar with sometimes eosinophilic and/or fine-granular cytoplasm and round-to-ovoid nuclei lacking atypia. Some cells were located between epithelial...Continue Reading

Citations

Sep 23, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinobu Masuda
Jul 17, 2013·Histopathology·Tomonori KawasakiAnna Sapino
Apr 5, 2014·BioMed Research International·David L WachterAbbas Agaimy
Nov 4, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yani WeiBing Wei

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