Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies.

Cold Spring Harbor Perspectives in Medicine
Loredana PucaHimisha Beltran

Abstract

Although a de novo clinical presentation of small cell neuroendocrine carcinoma of the prostate is rare, a subset of patients previously diagnosed with prostate adenocarcinoma may develop neuroendocrine features in later stages of castration-resistant prostate cancer (CRPC) progression as a result of treatment resistance. Despite sharing clinical, histologic, and some molecular features with other neuroendocrine carcinomas, including small cell lung cancer, castration-resistant neuroendocrine prostate cancer (CRPC-NE) is clonally derived from prostate adenocarcinoma. CRPC-NE therefore retains early prostate cancer genomic alterations and acquires new molecular changes making them resistant to traditional CRPC therapies. This review focuses on recent advances in our understanding of CRPC-NE biology, the transdifferentiation/plasticity process, and development and characterization of relevant CRPC-NE preclinical models.

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Mar 14, 2018·Cold Spring Harbor Perspectives in Medicine·David P Labbé, Myles Brown
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Jan 19, 2020·Nature Communications·Yota YasumizuDonald Kufe
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Jan 20, 2020·Molecular Aspects of Medicine·Delila Gasi Tandefelt, Johann de Bono
Oct 15, 2021·Der Pathologe·V W SailerJ Köllermann

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