PMID: 11338071May 8, 2001Paper

Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer

European Journal of Gastroenterology & Hepatology
P GrabowskiH Scherübl

Abstract

To determine the prognostic relevance of neuroendocrine differentiation in colorectal cancer. The survival of 116 patients with colorectal cancer of stages III (n = 59) and IV (n = 57) was correlated with the extent of neuroendocrine differentiation. Chromogranin A and synaptophysin were used as neuroendocrine markers. Based on the degree of immunoreactivity for these markers, tumours were classified as 0 (no expression of neuroendocrine markers), 1 (< 2% cells staining positive for neuroendocrine markers) and 2 (> 2% cells staining positive for neuroendocrine markers). Patients were followed up for more than 5 years or until death. Seven of 59 (11.8%) stage III cancers and 13/57 (22.8%) stage IV cancers belonged to group 2. The 96 patients of groups 0 and 1 lived for 48.9 months, whereas the 20 patients of group 2 survived for only 18.6 months (Kaplan-Meier survival curves, P < 0.001). The difference was most striking in stage III disease with 79.4 months' survival for combined groups 0 and 1, and 38.9 months' survival for group 2 (P < 0.01). Using the multivariate Cox regression model, the presence of more than 2% of cells with neuroendocrine differentiation was found to be an independent prognostic parameter for stage III an...Continue Reading

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Citations

Jun 20, 2003·The New England Journal of Medicine·Hans Scherübl, Patricia Grabowski
Jun 1, 2013·Indian Journal of Dermatology·Catharina FluehlerGiusto Trevisan
Feb 20, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yu-Jie ZengZhong-Hua Chu
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Katharina SchelwiesPeter T Daniel
Feb 20, 2010·Trends in Molecular Medicine·Natalia PrevarskayaYaroslav Shuba
Jan 31, 2009·Seminars in Oncology·David R SpigelF Anthony Greco
Feb 6, 2008·Seminars in Cancer Biology·Frank EntschladenKurt S Zaenker
May 22, 2004·Annals of the New York Academy of Sciences·Patricia GrabowskiHans Scherübl
Jul 23, 2008·International Journal of Cancer. Journal International Du Cancer·Christian N ArnoldHubert E Blum
May 28, 2011·Biochimica Et Biophysica Acta·Mario MancinoVanessa Almendro
Sep 6, 2006·The Journal of Medical Investigation : JMI·Hidenori MiyamotoMitsuo Shimada
Sep 10, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ji Y ParkYoon-Koo Kang
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia Grabowski, Hans Scherübl
Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Marco VolanteMauro Papotti
Jun 3, 2004·International Journal of Surgical Pathology·Linetta B KoppertWinand N M Dinjens
Apr 18, 2009·International Journal of Surgical Pathology·Yong Beom ChoHo-Kyung Chun
Sep 3, 2010·Virchows Archiv : an International Journal of Pathology·Marco VolanteMauro Papotti
Jan 31, 2003·British Journal of Cancer·P GrabowskiH Scherübl
Jan 2, 2020·Journal of Cutaneous Pathology·Kenta KobayashiShin-Ichi Ansai
Feb 11, 2015·Diseases of the Colon and Rectum·Hammad ShafqatAdam J Olszewski
Apr 8, 2003·World Journal of Gastroenterology : WJG·Gen-You YaoPei-Hui Chen
Nov 12, 2015·World Journal of Gastroenterology : WJG·Britta Kleist, Micaela Poetsch
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kerstin MaaserHans Scherübl
Apr 11, 2021·Biochemical Pharmacology·Michelle Melgarejo da RosaMoacyr Jesus Barreto de Melo Rego
Jun 1, 2006·Annales de pathologie·Valérie Hervieu, Jean-Yves Scoazec

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