Neuroendocrine mechanisms in pregnancy and parturition

Endocrine Reviews
F PetragliaJohn R G Challis

Abstract

The complex mechanisms controlling human parturition involves mother, fetus, and placenta, and stress is a key element activating a series of physiological adaptive responses. Preterm birth is a clinical syndrome that shares several characteristics with term birth. A major role for the neuroendocrine mechanisms has been proposed, and placenta/membranes are sources for neurohormones and peptides. Oxytocin (OT) is the neurohormone whose major target is uterine contractility and placenta represents a novel source that contributes to the mechanisms of parturition. The CRH/urocortin (Ucn) family is another important neuroendocrine pathway involved in term and preterm birth. The CRH/Ucn family consists of four ligands: CRH, Ucn, Ucn2, and Ucn3. These peptides have a pleyotropic function and are expressed by human placenta and fetal membranes. Uterine contractility, blood vessel tone, and immune function are influenced by CRH/Ucns during pregnancy and undergo major changes at parturition. Among the others, neurohormones, relaxin, parathyroid hormone-related protein, opioids, neurosteroids, and monoamines are expressed and secreted from placental tissues at parturition. Preterm birth is the consequence of a premature and sustained acti...Continue Reading

References

Nov 26, 1976·Science·G WeissB G Steinetz
Jan 1, 1975·Journal of Perinatal Medicine·E Müller-Tyl, J Lempert
Dec 1, 1992·Cell and Tissue Research·R KarmaliJ J Vanderhaeghen
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J E FergusonM E Bruns
Apr 1, 1992·American Journal of Obstetrics and Gynecology·W B WarrenR S Goland
Apr 1, 1992·British Journal of Obstetrics and Gynaecology·L K PetersenN Uldbjerg
Jun 12, 1992·Science·D L LefebvreH H Zingg
Nov 1, 1991·American Journal of Obstetrics and Gynecology·A R FuchsE Behnke
Jan 1, 1990·Acta Obstetricia Et Gynecologica Scandinavica·F FacchinettiA R Genazzani
Oct 1, 1990·Brain Research. Molecular Brain Research·Y HaraH Gainer
Apr 1, 1989·American Journal of Perinatology·T Chard
Jul 1, 1989·The Journal of Endocrinology·D P BehanP J Lowry
Mar 16, 1989·Biochimica Et Biophysica Acta·T AudhyaB Hutchinson
Aug 1, 1989·The Journal of Clinical Endocrinology and Metabolism·F PetragliaA R Genazzani
Feb 28, 1989·Biochemical and Biophysical Research Communications·S A Jones, J R Challis
May 1, 1988·The Journal of Clinical Endocrinology and Metabolism·A N MargiorisG P Chrousos
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B G RobinsonJ A Majzoub
Feb 1, 1988·The Journal of Clinical Endocrinology and Metabolism·S BelisleS Lemaire
Jan 1, 1987·Biology of the Neonate·K NagashimaT Kuroume
Nov 1, 1986·The Journal of Clinical Endocrinology and Metabolism·R S GolandA G Frantz
Jan 1, 1988·Cytogenetics and Cell Genetics·J L ArbiserJ A Majzoub
Jun 30, 1988·Biochemical and Biophysical Research Communications·E C ChanR Smith

❮ Previous
Next ❯

Citations

Jul 4, 2013·Clinical Obstetrics and Gynecology·Charles E Wood
May 9, 2012·Biological Reviews of the Cambridge Philosophical Society·Steven W GangestadMelissa A Eaton
Oct 15, 2013·Journal of Psychosomatic Research·Janet A DiPietroPing Chen
Jan 1, 2013·ISRN Neuroscience·Hai-Peng YangStephani C Wang
Mar 28, 2013·American Journal of Epidemiology·Carol J R HogueUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network Wr
Jun 19, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·José Morales-RosellóAlfredo Perales-Marín
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Michela TorricelliFelice Petraglia
Sep 30, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nathalie ContiFelice Petraglia
May 21, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·José Morales RosellóAlfredo Perales Marín
Mar 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria De BonisFelice Petraglia
Sep 23, 2011·Stress : the International Journal on the Biology of Stress·Charlotte HellgrenInger Sundström Poromaa
Feb 4, 2016·American Journal of Reproductive Immunology : AJRI·Faranak BehniaRamkumar Menon
Dec 23, 2011·International Journal of Endocrinology·Nikolaos VrachnisZoe Iliodromiti
Dec 15, 2015·Physiology & Behavior·Grace Violeta Espinoza PardoAldo Bolten Lucion
Jul 20, 2012·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Janet A Dipietro
Jun 5, 2012·Fertility and Sterility·Felice PetragliaCharles Chapron
Sep 6, 2011·Clinics in Perinatology·Pathik D WadhwaMichael C Lu
Jul 23, 2011·Molecular and Cellular Endocrinology·James Olcese
Nov 21, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Romina NovembriFelice Petraglia
Aug 2, 2015·American Journal of Obstetrics and Gynecology·Roberto RomeroLeonid Margolis
Jul 4, 2012·Developmental Neurobiology·Elaine Y Hsiao, Paul H Patterson
Nov 10, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Heather J Hamlin
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Guoyao WuAmy Webb Girard
Nov 22, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·H K BrownM K Campbell
Mar 19, 2015·Reproductive Toxicology·Chandrew RajakumarKaiping Yang
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·James L Thomas, Himangshu S Bose
Mar 4, 2015·Neuroscience Bulletin·Phillipe Leff GelmanJuan Pablo Reyes Grajeda
Sep 11, 2012·American Journal of Obstetrics and Gynecology·Steve N CaritisUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Greti Aguilera
Dec 23, 2011·Vaccine·Douglas C Hodgins, Patricia E Shewen
Dec 25, 2012·Placenta·J ChallisA Bocking

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Roger Smith
Best Practice & Research. Clinical Obstetrics & Gynaecology
Graham J Burton, Eric Jauniaux
Journal of Reproductive Immunology
S N KalantaridouG P Chrousos
© 2021 Meta ULC. All rights reserved