Neuroendocrine Neoplasms of the Sinonasal Tract: Neuroendocrine Carcinomas and Olfactory Neuroblastoma

Head and Neck Pathology
Ketan Shah, Bayardo Perez-Ordoñez

Abstract

Neuroendocrine neoplasms (NENs) can occur in organs or tissues that do not contain neuroendocrine cells normally and do not necessarily imply embryologic derivation from the neuroectoderm; but rather reflect a shared phenotype characterized by the expression of multiple genes encoding both endocrine and neuronal features. NENs are rare in the sinonasal tract and are subdivided into epithelial and neural subtypes based on the presence of keratins or neurofilaments, respectively. Although relatively rare, neuroendocrine carcinomas (NECs) and olfactory neuroblastoma (ONB) are the most common neuroendocrine neoplasms of the sinonasal tract. The focus of this review is to highlight recent developments in the pathology of sinonasal NECs and ONB in light of the upcoming update of the World Health Organization (WHO) 2005 classification of tumors of the head and neck.

References

Jul 1, 1984·Pathology, Research and Practice·U Siwersson, L G Kindblom
Jun 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·S L MyersJ Shiffman
May 1, 1993·Neurosurgery·A MoritaL M Quast
Mar 21, 2002·The Lancet Oncology·P DulguerovT C Calcaterra
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stacey E Mills
Feb 3, 2007·Seminars in Oncology·Gregory Renner
Mar 21, 2007·Archives of Otolaryngology--head & Neck Surgery·Daniel JethanamestDavid I Kutler
Apr 15, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mohamed GuledEdward B Stelow
Sep 3, 2008·The Journal of Laryngology and Otology·T Galm, N Turner
Nov 11, 2009·Auris, Nasus, Larynx·Atsuko FurutaHarumi Suzaki
Oct 29, 2010·Ear, Nose, & Throat Journal·Michael W ChuJoseph K Han
Nov 26, 2010·Head and Neck Pathology·Sara HafeziIlan Weinreb
Jul 29, 2011·Head & Neck Oncology·Anna LikhachevaAdel K El-Naggar
Sep 15, 2011·Head and Neck Pathology·Timothy BatesMax Robinson
Oct 26, 2011·Oral Oncology·Kimihide KusafukaLeon Barnes
Oct 26, 2012·The American Journal of Surgical Pathology·Justin A BishopWilliam H Westra
Mar 7, 2013·Head and Neck Pathology·Christopher A French
Oct 2, 2013·Journal of Neurological Surgery. Part B, Skull Base·Jamie J Van GompelMichael J Link
Dec 19, 2013·The Laryngoscope·Joanne RimmerDavid Howard
Jun 5, 2015·Head & Neck·Diana BellAlfio Ferlito

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Citations

Feb 14, 2018·The American Journal of Surgical Pathology·Lisa M RooperWilliam H Westra
Jan 18, 2018·Acta neurochirurgica·Kenny YuKanna Gnanalingham
Jan 10, 2018·Der Pathologe·B KonukiewitzG Klöppel
Aug 4, 2018·Journal of Neurosurgery·Gary L GalliaMasaru Ishii
Mar 7, 2018·Scientific Reports·Alejandro López-HernándezMario Hermsen
Jul 15, 2020·Head and Neck Pathology·Kent M SwimleyLester D R Thompson
Jul 10, 2016·Head and Neck Pathology·Martina MandaranoAngelo Sidoni
Mar 6, 2019·Ear, Nose, & Throat Journal·Duy Quoc NgoQuang Van Le
Feb 20, 2018·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Albina Venus, Sangita Sharma Mehta
Aug 8, 2019·Head and Neck Pathology·Jonathan E AttwoodKetan A Shah
Jun 5, 2020·Surgical Neurology International·Wilson P LaoSteve C Lee
Jan 20, 2021·BMJ Case Reports·Mohammad FarwanaPavol Surda
Aug 4, 2021·Journal of Neuroendocrinology·Jain PranteshAmr Mohamed
Sep 28, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Norton StephenJagadesan Pandjatcharam

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