Neuroendocrine phenotype as an acquired resistance mechanism in ALK-rearranged lung adenocarcinoma

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Charline CaumontJean-Philippe Merlio

Abstract

A 63-year-old caucasian woman, presenting with metastatic primitive lung adenocarcinoma was treated with ALK inhibitor crizotinib treatment for six month. After rapid regression of all known lesions, tumor progression appeared six month later on all the already known lesions. A biopsy of subclavicular lymphadenopathy revealed a carcinoma with neuroendocrine phenotype with both immunohistochemical expression of ALK protein and ALK-rearrangement. It was associated with acquired resistance to crizotinib with ALK-rearrangement but without point mutation or amplification of the ALK gene. We herein report the first case of histological neuroendocrine transformation after ALK inhibitor crizotinib treatment, associated with acquired resistance to crizotinib.

References

Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Jan 27, 2012·Science Translational Medicine·Ryohei KatayamaJeffrey A Engelman
Feb 14, 2012·Nature Medicine·Kengo TakeuchiYuichi Ishikawa
Jan 15, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S PopatM O'Brien
Apr 27, 2013·Journal of Clinical Pathology·Harumi NakamuraHitoshi Tsuda
Jul 17, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yoshihisa KobayashiYasushi Yatabe
Jan 25, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Emma NorkowskiVincent Thomas de Montpréville
May 16, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Naoki OmachiShinji Atagi

❮ Previous
Next ❯

Citations

Sep 14, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nancy K Gillis, Howard L McLeod
May 11, 2016·Journal of Pathology and Translational Medicine·Soomin AhnWoong-Yang Park
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sai-Hong Ignatius OuSiraj M Ali
Oct 12, 2019·Nature Reviews. Drug Discovery·Soufiane Boumahdi, Frederic J de Sauvage
Jun 11, 2020·American Journal of Clinical Oncology·Gerald ClamonTaher A Hejleh
Sep 29, 2019·Cancer Biology & Therapy·Na LiuYu Yao
Sep 6, 2020·American Journal of Clinical Oncology·Gerald ClamonTaher A Hejleh
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ferdinandos Skoulidis, Vassiliki A Papadimitrakopoulou
Jun 7, 2019·Clinical Lung Cancer·Julian PinsolleAnne McLeer-Florin
Jul 23, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Pamela Abdayem, David Planchard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Daniel B Costa, Susumu Kobayashi
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Yoshihisa KobayashiYasushi Yatabe
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Naoki OmachiShinji Atagi
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Yoon Jin ChaHyo Sup Shim
© 2022 Meta ULC. All rights reserved