Neuroendocrine Regulation of Air Pollution Health Effects: Emerging Insights

Toxicological Sciences : an Official Journal of the Society of Toxicology
Samantha J SnowUrmila P Kodavanti

Abstract

Air pollutant exposures are linked to cardiopulmonary diseases, diabetes, metabolic syndrome, neurobehavioral conditions, and reproductive abnormalities. Significant effort is invested in understanding how pollutants encountered by the lung might induce effects in distant organs. The role of circulating mediators has been predicted; however, their origin and identity have not been confirmed. New evidence has emerged which implicates the role of neuroendocrine sympathetic-adrenal-medullary (SAM) and hypothalamic-pituitary-adrenal (HPA) stress axes in mediating a wide array of systemic and pulmonary effects. Our recent studies using ozone exposure as a prototypical air pollutant demonstrate that increases in circulating adrenal-derived stress hormones (epinephrine and cortisol/corticosterone) contribute to lung injury/inflammation and metabolic effects in the liver, pancreas, adipose, and muscle tissues. When stress hormones are depleted by adrenalectomy in rats, most ozone effects including lung injury/inflammation are diminished. Animals treated with antagonists for adrenergic and glucocorticoid receptors show inhibition of the pulmonary and systemic effects of ozone, whereas treatment with agonists restore and exacerbate the o...Continue Reading

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Citations

Dec 6, 2018·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Hyunmee KimJungwoo Sohn
Feb 14, 2019·Journal of Toxicology and Environmental Health. Part a·Samantha J SnowUrmila P Kodavanti
Jun 21, 2019·Dose-response : a Publication of International Hormesis Society·Yehoshua SocolMoshe Yanovskiy
Aug 21, 2019·International Journal of Molecular Sciences·Mirco GalièManuela Malatesta
Sep 26, 2019·Environmental Health Perspectives·Cole BrokampPatrick Ryan
Aug 10, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andres R HenriquezUrmila P Kodavanti
Jun 18, 2020·Frontiers in Bioengineering and Biotechnology·Jia-Wei YangGuan-Yu Chen
Dec 16, 2020·Journal of Toxicology and Environmental Health. Part a·Devin I AlewelUrmila P Kodavanti
Mar 5, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Catherine H ColonnaUrmila P Kodavanti
Nov 21, 2020·Toxicology and Applied Pharmacology·Samantha J SnowUrmila P Kodavanti
Jun 6, 2021·The Science of the Total Environment·Ching-Yu LinTsun-Jen Cheng
Jul 1, 2021·Environmental Health : a Global Access Science Source·Chelsea A Weitekamp, Hans A Hofmann
Aug 3, 2021·Journal of Hazardous Materials·Cuiping WangHaidong Kan
Jun 18, 2021·American Journal of Respiratory and Critical Care Medicine·John R Balmes

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