Neuroendocrine responses regulating susceptibility and resistance to autoimmune/inflammatory disease in inbred rat strains

Immunological Reviews
L TonelliE M Sternberg

Abstract

Rodent animal models of inflammatory and autoimmune disease have been important tools in the study of the interaction between neuroendocrine physiology and the immune responses. The rat has been particularly useful in part because, in contrast to other species, most rat models of autoimmune/inflammatory disease are induced rather than spontaneous. This allows for systematic and controlled manipulations of the neuroendocrine system in relation to exposure to the antigen or proinflammatory trigger. The most frequently used immune challenges include lipopolysaccharide-induced septic shock, carrageenan-induced local inflammation and adjuvant or bacterial cell wall-induced arthritis. By analyzing the responses to these challenges in different strains of rats and mice it has been possible to define the relationships between the neuroendocrine and immune systems and to identify some mechanisms through which these connections confer susceptibility and resistance to autoimmune and inflammatory diseases. The present review will discuss data obtained from rodent physiology, indicating that an important component in the susceptibility or resistance to development of these diseases is due to dysfunctional regulation of the immune response b...Continue Reading

Citations

Apr 20, 2005·Regulatory Peptides·Ana M PuyóBelisario E Fernández
Jan 1, 2003·Journal of Neuroimmunology·Michael PuchowiczEsther M Sternberg
Jun 28, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leonardo H TonelliTeodor T Postolache
Jun 24, 2005·Infection and Immunity·Mahtab MoayeriEsther M Sternberg
Sep 18, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joan Y Summy-Long, Sanmei Hu
Jan 23, 2013·Pediatrics·Sara B JohnsonJenna Riis
Jun 10, 2003·Annals of the New York Academy of Sciences·Angelika Buske-Kirschbaum, Dirk H Hellhammer
Jun 16, 2006·Journal of Neuroendocrinology·K Fecho, J G Valtschanoff
Apr 11, 2006·Brain, Behavior, and Immunity·Karamarie FechoCharles P Schmitt
May 11, 2016·Scientific Reports·Sebastian A SchneiderThomas Roeder

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