PMID: 6409929Jul 1, 1983Paper

Neuroendocrine responses to glucose ingestion in man. Specificity, temporal relationships, and quantitative aspects

The Journal of Clinical Investigation
T F TseP E Cryer

Abstract

The mechanisms of postprandial glucose counterregulation-those that blunt late decrements in plasma glucose, prevent hypoglycemia, and restore euglycemia-have not been fully defined. To begin to clarify these mechanisms, we measured neuroendocrine and metabolic responses to the ingestion of glucose (75 g), xylose (62.5 g), mannitol (20 g), and water in ten normal human subjects to determine for each response the magnitude, temporal relationships, and specificity for glucose ingestion. Measurements were made at 10-min intervals over 5 h. By multivariate analysis of variance, the plasma glucose (P < 0.0001), insulin (P < 0.0001), glucagon (P < 0.03), epinephrine (P < 0.0004), and growth hormone (P < 0.01) curves, as well as the blood lactate (P < 0.0001), glycerol (P < 0.001), and beta-hydroxybutyrate (P < 0.0001) curves following glucose ingestion differed significantly from those following water ingestion. However, the growth hormone curves did not differ after correction for differences at base line. In contrast, the plasma norepinephrine (P < 0.31) and cortisol (P < 0.24) curves were similar after ingestion of all four test solutions, although early and sustained increments in norepinephrine occurred after all four test solut...Continue Reading

References

Jan 1, 1976·Annual Review of Biochemistry·H G Hers
Nov 1, 1978·The Journal of Clinical Endocrinology and Metabolism·L SaccaR S Sherwin
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J E LiljenquistD Rabinowitz
Jun 1, 1978·Metabolism: Clinical and Experimental·J RadziukJ Dupre
Aug 1, 1978·The Journal of Clinical Investigation·G I ShulmanA D Cherrington
May 1, 1974·The Journal of Clinical Investigation·R S SherwinR Andres
Aug 19, 1971·The New England Journal of Medicine·R H Unger
Nov 1, 1968·Annals of Internal Medicine·D M Kipnis
Nov 1, 1966·The Journal of Clinical Investigation·G F CahillD M Kipnis
Aug 1, 1967·Archives of Biochemistry and Biophysics·J K PinterJ A Watson
Mar 1, 1981·Diabetes·P E Cryer
Aug 21, 1980·The New England Journal of Medicine·P E Cryer
Sep 1, 1980·Metabolism: Clinical and Experimental·S WelleR G Campbell
Oct 1, 1980·Annals of Internal Medicine·S HamburgR S Sherwin
Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·F SanteusanioP Brunetti
Jun 1, 1981·The Journal of Clinical Endocrinology and Metabolism·H ShamoonR S Sherwin
Oct 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J Kleinbaum, H Shamoon
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE

❮ Previous
Next ❯

Citations

Jan 1, 1986·Journal of Neural Transmission·S Welle, J Feldman
Jun 1, 1997·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·S Puvi-RajasinghamC J Mathias
Jan 1, 1986·Experimental Gerontology·R P ToninoJ W Rowe
Apr 1, 1997·Physiology & Behavior·J Overduin, A Jansen
Nov 1, 1984·Clinics in Endocrinology and Metabolism·L Landsberg, J B Young
Jul 25, 1985·The New England Journal of Medicine·P E Cryer, J E Gerich
Nov 1, 1989·The Journal of Clinical Investigation·C BerneF Niklasson
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jackie A ClowesRichard Eastell
Jun 1, 1989·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·I W FellowsI A Macdonald
Mar 1, 1985·Metabolism: Clinical and Experimental·R S SchwartzD C Robbins
Jul 7, 2005·Circulation·Roldano ScognamiglioAngelo Avogaro
Nov 5, 1997·Annals of the New York Academy of Sciences·J KoskaM Vigas
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Jackie A ClowesAubrey Blumsohn
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Jackie A ClowesAubrey Blumsohn
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Paolo ViciniClaudio Cobelli
Jun 1, 1987·The American Journal of Physiology·P Diamond, J LeBlanc
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·A NakagawaH Nakabayashi
Jul 1, 1991·The American Journal of Physiology·Z ChapJ B Field
Jul 1, 1984·The American Journal of Physiology·N J ChristensenS Madsbad
May 1, 1989·The American Journal of Physiology·P J BoyleP E Cryer
Feb 1, 1993·The American Journal of Physiology·P E Cryer
May 1, 1991·The American Journal of Physiology·I B HirschP E Cryer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.