PMID: 2505296Jan 1, 1989Paper

Neuroendocrine responses to nicotine and stress: enhancement of peripheral stress responses by the administration of nicotine

Psychopharmacology
D E Morse

Abstract

Habitual smokers frequently report that when they are stressed smoking helps them to relax. One potential explanation for the reported stress ameliorating effect of smoking is that cigarette consumption (nicotine self-administration) may decrease the sympathetic autonomic nervous system activity which is associated with the stress response. In the present study, rabbits prepared with chronic vascular cannulae were used to study the effects of nicotine administration on plasma corticosterone, catecholamine (epinephrine, norepinephrine and dopamine) and glucose responses to physical restraint stress. Nicotine (0.025, 0.05 or 0.10 mg nicotine base/kg body weight) was administered for 10 days prior to the "stress test" to allow for the development of habituation/tolerance to its acute toxic effects. Independent administration of nicotine, or the application of the physical restraint stressor, resulted in increases in the plasma concentrations of corticosterone, epinephrine, norepinephrine, and glucose. Nicotine administration during restraint stress enhanced the increase in plasma corticosterone and epinephrine, as compared to the responses induced by either factor alone. The results suggest that the stress ameliorating effect of c...Continue Reading

References

Apr 1, 1973·Journal of Personality and Social Psychology·R W Coan
Feb 1, 1971·The British Journal of Social and Clinical Psychology·C D Frith
Sep 1, 1983·Pharmacology, Biochemistry, and Behavior·N E GrunbergJ E Barrett
Sep 1, 1983·Journal of Human Stress·J M MacDougallR S Eliot
Jan 1, 1983·Addictive Behaviors·J E RoseM E Jarvik
May 1, 1982·Journal of Personality and Social Psychology·B Silverstein
Jan 1, 1980·Journal of Neuroscience Research·L R Durrett, M G Ziegler
Mar 1, 1958·Journal of Abnormal Psychology·C McARTHURJ DICKINSON

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Citations

Jan 1, 1994·Anxiety·J S McDanielJ Caudle
Jul 29, 2005·Journal of Behavioral Medicine·Brian K ManningJasjit S Ahluwalia
May 1, 1990·Pharmacology, Biochemistry, and Behavior·O F Pomerleau, C S Pomerleau
Nov 26, 2003·European Journal of Pharmacology·Anna Molander, Bo Söderpalm
Aug 26, 2000·European Journal of Pharmacology·E C DonnyA F Sved
Jun 11, 1998·Psychoneuroendocrinology·O F Pomerleau
Jul 1, 1998·Pharmacology & Toxicology·Y K FungD B Kimmel
Apr 28, 2006·Behavioral Medicine·Jason D Robinson, Paul M Cinciripini
Feb 26, 2016·Physiology & Behavior·Anne Q Fosnocht, Lisa A Briand
May 1, 1991·British Journal of Addiction·O F Pomerleau, C S Pomerleau
Jun 16, 2007·Biological Psychiatry·Andras Bilkei-GorzoAndreas Zimmer
Jul 14, 2004·European Journal of Pharmacology·Charles T StierEsther L Sabban
Mar 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Terril L VerplaetseSherry A McKee
Mar 1, 1992·Developmental Medicine and Child Neurology·S Tong, A J McMichael
Jan 7, 1998·Journal of Applied Physiology·J E Fewell, P A Tang

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