PMID: 6111824Jan 1, 1981Paper

Neuroendocrine tests during treatment with neuroleptic drugs: I. Plasma prolactin response to chlorpromazine challenge

Psychopharmacology
T KolakowskaJ Knox

Abstract

Chlorpromazine (CPZ) 50 mg IM was administered to 21 schizophrenics receiving neuroleptic treatment. A further increase in plasma prolactin (PRL) was provoked in 8 subjects who had lower daily doses of neuroleptics than the remainder. The difference in the baseline PRL concentrations between the subgroups was inconsistent. In some patients, the test dose produced no change in plasma PRL but a further PRL rise was induced by raising the challenge dose or by an increase in the daily dose of neuroleptics. It is concluded that the PRL rise following CPZ 50 mg IM identifies some patients whose PRL response to the current treatment was only submaximal but the absence of PRL increment after this test dose is not sufficient evidence that the baseline level was already maximal.

References

Jan 1, 1978·Archives of General Psychiatry·P H GruenF S Halpern
Oct 1, 1978·Archives of General Psychiatry·P G GruenF S Halpern
Oct 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·T KolakowskaM Franklin
Jan 1, 1974·Annual Review of Medicine·G L Klerman

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Citations

Nov 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·T KolakowskaS Fraser
Mar 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·J C CooksonL Rees
Feb 1, 1990·DICP : the Annals of Pharmacotherapy·J M ZitoJ Jaeger
Nov 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·L E Braddock, I M Blake
Nov 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·T KolakowskaM Gelder

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