Neuroendocrine Tumors in Pediatrics

Global Pediatric Health
Zainab Azam Farooqui, Aman Chauhan

Abstract

Neuroendocrine cells are dispersed diffusely throughout many organ systems in the body and hence neuroendocrine tumors (NETs) can arise from almost anywhere in the body. NETs are considered rare tumors, and the current incidence is reported to be about 6 cases in 100 000 in adults and about 2.8 cases per million in the pediatric age group. Despite the indolent nature of these tumors, they have the potential for metastasis and significant morbidity. NETs can be asymptomatic at the time of diagnosis or can present with flushing, diarrhea, wheezing, weight loss, and fatigue among other symptoms. Due to the ambiguity of presenting symptoms, it is not uncommon for NETs to be diagnosed late in the disease course. Despite low incidence, the prevalence of the disease is high since patients live for many years and sometimes decades. Early detection of well-differentiated NETs has excellent outcomes with the majority of early-stage diseases being cured with surgical resection alone. There have been recent advancements in the management of metastatic progressive NETs with approval of peptide receptor radionuclide therapy, telotristat, and everolimus. Awareness of these rare tumors and its management is crucial for optimal management. This...Continue Reading

References

May 1, 1993·Chest·L T WangH H Bode
Feb 9, 2005·Journal of Pediatric Gastroenterology and Nutrition·Patrizia Dall'IgnaGiovanni Cecchetto
Oct 2, 2007·Pediatric Radiology·Geetika KhannaYutaka Sato
Jan 8, 2008·The Lancet Oncology·Irvin M ModlinAnders Sundin
Jul 21, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Vikas PrasadRichard P Baum
Dec 10, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jan FrankoA James Moser
Feb 26, 2011·Endocrinology and Metabolism Clinics of North America·Marie-Ellen Sarvida, M Sue O'Dorisio
Sep 7, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Giovanni MarchegianiMassimo Falconi
Oct 26, 2011·Endocrine-related Cancer·Günter Klöppel
May 2, 2012·Journal of Pediatric Hematology/oncology·Della L Howell, M Sue O'Dorisio
Jun 9, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·Matthew H KulkeUNKNOWN National Comprehensive Cancer Networks
Sep 26, 2013·AJR. American Journal of Roentgenology·Kyung Won KimNikhil H Ramaiya
Jun 12, 2014·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Esra KarakuşAyşe Dursun
May 1, 2015·Neuroendocrinology·Anna KoumarianouNicola Fazio
Oct 6, 2015·World Journal of Radiology·David BonekampElliot K Fishman
Oct 21, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura H TangDavid S Klimstra
Nov 29, 2015·Hematology/oncology Clinics of North America·Aaron I Vinik, Celine Chaya
Dec 26, 2015·Lancet·James C YaoUNKNOWN RAD001 in Advanced Neuroendocrine Tumours, Fourth Trial (RADIANT-4) Study Group
Dec 30, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samira M SadowskiElectron Kebebew
Jan 6, 2016·Neuroendocrinology·U-F PapeUNKNOWN Vienna Consensus Conference participants
Mar 1, 2016·Archives of Medical Science : AMS·Paweł GutMarek Ruchała
Dec 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew H KulkeMarianne Pavel
Dec 14, 2016·British Journal of Cancer·I J DietsM C J Jongmans
Jan 12, 2017·The New England Journal of Medicine·Jonathan StrosbergUNKNOWN NETTER-1 Trial Investigators
Apr 2, 2017·Journal of Pediatric Surgery·Inna N LobeckDaniel von Allmen
May 4, 2017·Urology Case Reports·Aidan McGowanAdam R Metwalli
Jul 29, 2017·Frontiers in Pediatrics·Reshma Bholah, Timothy Edward Bunchman
Oct 31, 2017·Rare Tumors·Cláudia Vaz GuerreiroMaria Teresa Almodovar
Dec 7, 2017·Clinical Endoscopy·Dong Wook LeeHo Gak Kim
Dec 20, 2017·Biologics : Targets & Therapy·Hanford YauAndreas G Moraitis
Mar 15, 2018·Annals of Hepato-biliary-pancreatic Surgery·Jiyoung BuDong Wook Choi
May 4, 2018·Oncotarget·Aman ChauhanLowell B Anthony

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Methods Mentioned

BETA
surgical resection
imaging techniques
surgical resections

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