Neuroendocrine Tumors of the Breast

Archives of Pathology & Laboratory Medicine
Lauren Elizabeth Rosen, Paolo Gattuso

Abstract

Primary neuroendocrine tumors of the breast are a rare and underrecognized subtype of mammary carcinoma. Neuroendocrine tumors of the breast occur predominately in postmenopausal women. The tumors are subclassified into well-differentiated and poorly differentiated neuroendocrine tumors, and invasive breast carcinoma with neuroendocrine features. Well-differentiated tumors show architectural similarity to carcinoids of other sites but lack characteristic neuroendocrine nuclei. Poorly differentiated neuroendocrine tumors are morphologically identical to small cell carcinoma of the lung. Neuroendocrine differentiation, seen in up to 30% of invasive breast carcinomas, is most commonly associated with mucinous and solid papillary carcinomas. The diagnosis of neuroendocrine differentiation requires expression of the neuroendocrine markers synaptophysin or chromogranin. The main differential diagnosis is a metastatic neuroendocrine tumor from an extramammary site. Neuroendocrine tumors of the breast are treated similarly to other invasive breast carcinomas. Although no consensus has been reached on the prognosis, most studies suggest a poor outcome.

References

Sep 8, 2000·The American Journal of Surgical Pathology·S J ShinP P Rosen
Jan 5, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A SapinoG Bussolati
Oct 9, 2003·Breast Cancer Research and Treatment·Ladislav TomesPeter H Watson
Mar 24, 2010·Seminars in Diagnostic Pathology·Luisella RighiGianni Bussolati
Mar 24, 2011·International Journal of Surgical Pathology·Cunxian ZhangW Dwayne Lawrence
Mar 15, 2012·Journal of Gastroenterology and Hepatology·Chan Hyuk ParkJeong Youp Park
Jun 6, 2013·World Journal of Surgical Oncology·Fernando A AngaritaLilian Torregrosa
Dec 11, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Julie Benedicte BraskVera Timmermans Wielenga
Apr 5, 2014·BioMed Research International·David L WachterAbbas Agaimy
Jul 24, 2014·AJR. American Journal of Roentgenology·Young Mi ParkWei Tse Yang
Nov 17, 2014·Breast Cancer Research and Treatment·Jordan M CloydIrene L Wapnir
Dec 15, 2015·The Oncologist·Alessandro InnoStefania Gori
Mar 29, 2016·The Breast : Official Journal of the European Society of Mastology·Shuangping GuoZhe Wang
Apr 30, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sambit K MohantyDeepti Dhall

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Citations

Mar 27, 2020·Medical Sciences : Open Access Journal·Ugo TestaElvira Pelosi
Mar 10, 2019·BMJ Case Reports·Luca ZaninPier Paolo Panciani
Mar 29, 2020·Cellular Oncology (Dordrecht)·B MahalakshmiBharath Kumar Velmurugan
May 18, 2020·Journal of Clinical Medicine·Azzurra IrelliMassimo De Martinis
Nov 11, 2020·Reviews in Endocrine & Metabolic Disorders·Stefano La Rosa, Silvia Uccella
Jan 12, 2021·International Journal of Surgical Pathology·Elsa SeijnhaeveMieke R Van Bockstal
Feb 10, 2021·Cancer Cytopathology·Shirley Kristina JamidiGary M Tse
Nov 4, 2020·Intractable & Rare Diseases Research·Nikolaos S Salemis
Feb 16, 2021·Frontiers in Endocrinology·Marco GalloAnnamaria Anita Livia Colao
Nov 7, 2020·Indian Journal of Pathology & Microbiology·Vishal SinghLovenish Bains
Aug 8, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xiaomei LiGang Hou
Sep 30, 2021·Journal of Medical Primatology·J Díaz-DelgadoG Gomez
Sep 29, 2020·Breast Care·Ramona Erber, Arndt Hartmann

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