PMID: 2980372Jan 1, 1987Paper

Neuroendocrinology of female reproduction: review, models, and potential approaches for risk assessment

Reproductive Toxicology
D L Hess


The central role of the mammalian hypothalamic-pituitary axis in regulating female reproductive cycles is reviewed. A variety of animal models and techniques that offer increased sensitivity, speed, and flexibility over traditional reproductive toxicologic approaches for short term testing or screening are discussed, including the pivotal analysis of gonadotrophin releasing hormone (GnRH) pulse generator activity in vivo and in vitro. Other neuroendocrine techniques that require further development, but provide potential approaches to demonstrate specific sites or mechanisms of action for toxic effects on the hypothalamic-pituitary axis are suggested.


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Dec 2, 1976·Nature·D K SarkarN M Sherwood
May 1, 1986·Annals of the Rheumatic Diseases·J C Buckland-WrightS R Walker
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Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jan 1, 1983·Endocrine Reviews·S P Kalra, P S Kalra
Jan 1, 1984·Cell and Tissue Research·I MerchenthalerB Flerkó
Sep 1, 1983·Journal of Reproduction and Fertility·M Ferin

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