Abstract
Gastroparesis (GP) is a syndrome characterized by delayed gastric emptying in association with symptoms of epigastric pain, nausea, and vomiting in the absence of mechanical obstruction. The prevalence of gastroparesis has been estimated at 24 per 100,000, with women more commonly affected than men. Diabetes appears to be the underlying cause in approximately 25 % of patients, while connective tissue disorders, autoimmune disorders, prior gastric surgery, ischemia, and medications make up a smaller percentage of the remaining identifiable causes. However, the largest group of GP patients falls into the idiopathic category (~50 %); many of these patients likely develop GP as a result of a prior viral infection. Symptoms of gastroparesis develop due to a number of different pathophysiologic processes, including disorders of fundic accommodation, antroduodenal dyscoordination, a weak antral pump, gastric dysrhythmias, abnormal duodenal feedback, and enhanced visceral sensation. Once the diagnosis of GP is made, the clinician has a number of different treatment options. For patients with mild to moderate symptoms, dietary modifications in conjunction with or without prokinetics and antiemetics are often all that is required. Howeve...Continue Reading
References
Dec 1, 1992·Gastroenterology·M P HockingC A Sninsky
Jan 1, 1991·European Journal of Nuclear Medicine·M HorowitzD J Shearman
Mar 1, 1989·Diabetologia·M HorowitzD J Shearman
Mar 1, 1972·The American Journal of Physiology·K A Kelly, R C La Force
May 1, 1997·Digestive Diseases and Sciences·B O FamiloniB Johnson
Nov 14, 1997·Gastroenterology·T TakahashiC Owyang
Mar 13, 1998·Gastroenterology·R W McCallumR A Ross
Nov 21, 1998·Digestive Diseases and Sciences·I SoykanR W McCallum
Apr 14, 1999·The American Journal of Gastroenterology·W A HoogerwerfM M Schuster
Jul 14, 2000·The American Journal of Gastroenterology·G TougasR W McCallum
Sep 21, 2000·The Journal of Clinical Investigation·C C WatkinsC D Ferris
Oct 4, 2000·Diabetes·T OrdögK M Sanders
Oct 12, 2000·Archives of Internal Medicine·D MalekiL J Melton
Mar 29, 2001·Digestive Diseases and Sciences·J P GuoH P Parkman
Jun 26, 2001·Diabetes Care·K L JonesM Horowitz
Sep 26, 2001·Archives of Internal Medicine·P BytzerM Horowitz
Dec 25, 2002·Digestive Diseases and Sciences·H PandeM D Crowell
Feb 18, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J H XingE Soffer
Aug 2, 2003·Gastroenterology·Thomas AbellWarren Starkebaum
Sep 1, 1963·Annals of Surgery·A M BILGUTAYC W LILLEHEI
Apr 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Z LinR W McCallum
Apr 28, 2004·Diabetes Care·Zhiyue LinRichard W McCallum
Nov 3, 2004·Gastroenterology·Henry P ParkmanUNKNOWN American Gastroenterological Association
May 17, 2005·Autonomic Neuroscience : Basic & Clinical·Chao QinRobert D Foreman
Nov 2, 2006·Digestive Diseases and Sciences·J H Xing, J D Z Chen
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Harvey A ZiessmanWilliam J Ravich
Oct 20, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Richard W McCallumZhiyue Lin
Mar 3, 2009·Gastroenterology·Hye-Kyung JungNicholas J Talley
Jun 10, 2009·World Journal of Surgery·Gregory O'GradyJohn A Windsor
Jun 12, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard W McCallumThomas Nowak
Dec 28, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard W McCallumIrene Sarosiek
Aug 3, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Zhiyue LinRichard W McCallum
Oct 19, 2012·European Journal of Gastroenterology & Hepatology·Guillaume GourcerolPhilippe Ducrotte
Nov 2, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I SarosiekR McCallum
Nov 14, 2012·The American Journal of Gastroenterology·Michael CamilleriUNKNOWN American College of Gastroenterology
Jul 16, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R W McCallumUNKNOWN TZP-102 Phase 2b Study Group
Nov 20, 2013·Journal of Minimal Access Surgery·Naga Venkatesh G JayanthiUNKNOWN Leeds Gastroparesis Multi-Disciplinary Team