Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizure susceptible Wistar rats

Epilepsy Research
N Garcia-CairascoL E Mello

Abstract

Acute audiogenic seizures are a model of generalized tonic-clonic seizures, induced by high intensity acoustic stimulation in genetically susceptible rodents. The neural substrate are sensory motor brainstem nuclei. Recruitment of forebrain structures takes places upon repetition of acoustically evoked seizures. The term audiogenic kindling means forebrain kindling evoked by repeated brainstem seizures and has been described in several strains of genetically epilepsy-prone rats. Thus, the present work was conducted in order to test the hypothesis that audiogenic kindling recruits the forebrain, which may be behaviorally evaluated and associated with morphological changes as well. The behavioral sequences observed during the development of audiogenic kindling were assessed by neuroethological methods (cluster analysis), with the ETHOMATIC program. Seizure severity indexes (brainstem and limbic seizures) and latencies of wild running and tonic-clonic seizures were measured to quantify seizure evolution. Densitometric analysis of Neo-Timm staining was used for assessing morphological changes associated with audiogenic kindling. In group I, II resistant (R) and 16 susceptible (S) animals were stimulated (120 dB) 21 times, and allow...Continue Reading

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Citations

Aug 7, 2013·Epilepsy Research·Melissa M Carballosa-GonzalezDolores E López
Nov 12, 2002·Brain Research·M C DorettoE Osório-Neto
Jun 5, 2003·Physiology & Behavior·Leida M Botion, Maria Carolina Doretto
Nov 17, 1998·Physiology & Behavior·N Garcia-CairascoF S Guimarães
Aug 15, 2000·Neuroscience and Biobehavioral Reviews·K C Ross, J R Coleman
May 9, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·S PonzoniN Garcia-Cairasco
Apr 20, 2000·Epilepsy Research·M F Dutra MoraesN Garcia-Cairasco
Aug 2, 2002·Epilepsy Research·J P LeiteE A Cavalheiro
Apr 10, 2008·Epilepsia·Lyudmila V Vinogradova, Clementina M van Rijn
Jul 18, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D D DamascenoA P Almeida
Mar 17, 2007·Brain Research·Lyudmila V VinogradovaLeena Tuomisto
Jan 11, 2001·Brain Research·N C CoimbraN Garcia-Cairasco
Sep 24, 2004·Neuroscience Letters·Lucas Henrique Maia MagalhãesMárcio Flávio Dutra Moraes
Jul 17, 2004·Epilepsy & Behavior : E&B·Norberto Garcia-CairascoMarcio de A Furtado
Oct 7, 2015·Epilepsy & Behavior : E&B·Gabriel Perfeito CastroMárcio Flávio Dutra Moraes
Jun 30, 2006·Epilepsy Research·Lyudmila V VinogradovaGalina D Kuznetsova
Aug 7, 2002·Biochemical and Biophysical Research Communications·Heloisa BeraldoMaria Carolina Doretto
Nov 28, 2013·Angewandte Chemie·Norberto Garcia-CairascoNorberto P Lopes
Nov 14, 2012·Epilepsy & Behavior : E&B·Julián TejadaNorberto Garcia-Cairasco
Mar 1, 2012·Epilepsy & Behavior : E&B·Daniel de Castro MedeirosMárcio Flávio Dutra Moraes
Jun 11, 2010·Clinical Science·Marilia G A G PereiraClaudio M Costa-Neto

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