Neurofibromatosis type 1 and optic pathway gliomas: follow-up of 54 patients

Sureka ThiagalingamK North


To describe the natural history of optic pathway gliomas (OPGs) in patients with neurofibromatosis type 1 (NF1), and to evaluate the current recommended guidelines for monitoring and follow-up of OPGs in this population. Retrospective case series. Patients with OPGs and NF1 seen in the neurofibromatosis clinic at the Children's Hospital at Westmead in Sydney, Australia. Patients with definite NF1 and confirmed OPGs were identified and their medical records searched to obtain data on demographics, details of the OPG diagnosis, and serial ophthalmic examination findings. Patients were stratified into groups according to age and mode of presentation. Visual acuity was recorded for each eye and grouped into mild (Snellen equivalent > or = 6/12), moderate (Snellen equivalent = 6/15-6/60), and severe (Snellen equivalent < 6/60) visual impairment at time of diagnosis, during follow-up, and at the most recent examination. Data were collected on 54 patients, the majority of whom (78%) were seen from 1990 to 2002, with an average follow-up of 8.6 years. The mean age at the time of OPG diagnosis was 5.2 years, with 32 patients having symptoms or signs at the time of diagnosis. Seventeen patients were diagnosed after the age of 6 years (ra...Continue Reading


Oct 1, 1977·The Australian and New Zealand Journal of Surgery·G L Klug
Oct 1, 1991·European Journal of Pediatrics·A M Lund, F Skovby
Dec 1, 1969·The British Journal of Ophthalmology·W F Hoyt, S A Baghdassarian
Sep 1, 1980·AJR. American Journal of Roentgenology·C G JacobyR A Beren
Mar 1, 1982·Brain : a Journal of Neurology·A Borit, E P Richardson
Aug 1, 1980·The British Journal of Ophthalmology·J E WrightN B Call
Dec 1, 1994·Neuropediatrics·C KuenzleE Boltshauser
Jun 27, 2000·Pediatric Neurosurgery·S M SchmandtJ Jane
Apr 24, 2001·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·G S GayreR M Siatkowski
Feb 1, 1964·Neurology·A M CHUTORIANS CARTER

❮ Previous
Next ❯


Dec 29, 2004·Annals of Neurology·M Livia BajenaruDavid H Gutmann
Jan 31, 2008·Pediatric Radiology·José Roberto Lopes Ferraz FilhoErika Cristina Pavarino-Bertelli
Jan 5, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jeong-Min HwangKyu-Chang Wang
Dec 25, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Roberto Jose DiazUte Bartels
Jun 6, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Masoud Aghsaei FardBahram Eshraghi
Feb 24, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Fangyu PengHarry T Chugani
Apr 8, 2009·Current Neurology and Neuroscience Reports·Kaleb Yohay
Aug 19, 2011·Current Treatment Options in Neurology·Simone L Ardern-Holmes, Kathryn N North
Jun 2, 2005·Neuroimaging Clinics of North America·Alfred L WeberNelson R Sabates
Aug 3, 2005·Nature Reviews. Cancer·Joshua B Rubin, David H Gutmann
Oct 5, 2006·Eye·L M Kaufman, O Doroftei
Jan 9, 2013·Neuro-oncology·Amy Lee ChongUte Bartels
Nov 19, 2004·Current Opinion in Pediatrics·Rhonda E Schnur
May 2, 2012·American Journal of Clinical Oncology·Ali VaranMünevver Büyükpamukçu
Dec 23, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kimberly Jett, Jan M Friedman
Jun 7, 2012·International Ophthalmology Clinics·Jane C Edmond
Aug 23, 2011·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Robert A AveryGrant T Liu
Jan 9, 2007·Journal of Paediatrics and Child Health·Fiona NobleMartin B Delatycki
Oct 21, 2009·Journal of Child Neurology·Angela J Sievert, Michael J Fisher
Jan 14, 2012·The Oncologist·Sachin Patil, Ronald S Chamberlain
Nov 17, 2007·Neurosurgical Focus·Mandy J BinningMarion L Walker
Feb 8, 2006·Neurosurgical Focus·Merdas Al-Otibi, James T Rutka
Mar 1, 2013·CNS Oncology·Iris FriedEric Bouffet
Oct 30, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G BlanchardL Lion Francois
Jul 26, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·C Van MierloC Cassiman
Jul 11, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ellen M ChungJason W Schroeder
Jul 12, 2011·Ophthalmic Plastic and Reconstructive Surgery·Efstathios T DetorakisIoannis G Pallikaris
May 28, 2013·European Journal of Pediatrics·Catherine CassimanIngele Casteels
Jan 27, 2006·Current Opinion in Ophthalmology·Christin L SylvesterRobert C Sergott
Aug 26, 2006·Current Opinion in Ophthalmology·Grant T Liu
Feb 6, 2015·Expert Review of Anticancer Therapy·Nicole M Brossier, David H Gutmann
Jan 10, 2008·Expert Review of Anticancer Therapy·Peter Pytel
Jan 25, 2008·Seminars in Ophthalmology·Aaron Savar, Dean M Cestari
Jan 18, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Gaelle BlanchardUNKNOWN NF France network
Mar 18, 2008·Journal of Neuropathology and Experimental Neurology·Fausto J RodriguezCaterina Giannini
Nov 11, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·J ShapeyA H Kaye
Dec 21, 2010·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Lan ChangFawn Leigh
May 11, 2010·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Laura SegalRobert C Polomeno
Apr 24, 2010·European Journal of Radiology·Minerva BeckerChristoph D Becker
Mar 23, 2010·Neuro-Chirurgie·G LenaA Paz-Paredes

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.