Neurofibromatosis type 1 and pregnancy

American Journal of Medical Genetics
L Dugoff, E Sujansky

Abstract

Neurofibromatosis Type 1 (NF-1) is an autosomal dominant condition which has markedly variable clinical expression, with manifestations ranging from mild cutaneous lesions to severe orthopedic complications and functional impairment. The current obstetrical literature indicates that women with NF-1 have increased complications associated with pregnancy. However, the majority of publications are case reports involving no more than 11 patients each, and are likely biased toward reporting on cases in which complications occurred. This study presents data on pregnancy outcome in 105 women with NF-1. The data were obtained from questionnaires completed by the study participants, and by review of their pregnancy and peripartum medical records. The 105 women had a total of 247 pregnancies, resulting in 182 live births, 44 first trimester spontaneous abortions, 21 elective terminations, and 2 ectopic pregnancies. There were two sets of twins. The cesarean section rate in our series (36%) was greater than the general population rate (9.1-23.5%). In 7 of these patients, the cesarean section was required because of maternal NF-1 complications. The study did not show the previously reported increased incidence of preeclampsia, preterm deli...Continue Reading

References

Nov 1, 1978·British Journal of Obstetrics and Gynaecology·G J Jarvis, A C Crompton
Mar 1, 1991·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J B SharmaS Malik
Aug 1, 1987·American Journal of Obstetrics and Gynecology·I Blickstein, M Lancet
May 1, 1973·The British Journal of Dermatology·G H Swapp, R A Main
Jun 1, 1983·British Journal of Obstetrics and Gynaecology·J N EdwardsD A Davey
Jun 15, 1984·American Journal of Obstetrics and Gynecology·S R BeltonV A Catanzarite

❮ Previous
Next ❯

Citations

Nov 16, 2006·Journal of Medical Genetics·Rosalie E FernerAmanda Kirby
Feb 8, 2006·Neurosurgical Focus·Merdas Al-Otibi, James T Rutka
Sep 8, 2006·European Journal of Human Genetics : EJHG·Rosalie E Ferner
Dec 14, 2011·Human Genomics·Sebastian Laycock-van SpykMeena Upadhyaya
Jun 27, 2015·The British Journal of Dermatology·E SbidianP Wolkenstein
Sep 4, 2012·The Spine Journal : Official Journal of the North American Spine Society·Bhavpreet S DhamJoseph V Campellone
Jan 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Therese M RothKate F Barald
Sep 23, 2008·Glia·Steven L Carroll, Nancy Ratner
Apr 14, 2006·International Journal of Immunogenetics·M GellerF P Nunes
Jan 18, 2013·American Journal of Medical Genetics. Part a·Claudia CesarettiFederica Natacci
Jun 9, 2012·American Journal of Medical Genetics. Part a·Piranit Nik KantaputraChanin Limwongse
Mar 22, 2005·La Revue de médecine interne·S Pinson, P Wolkenstein
Dec 6, 2008·Surgical Oncology Clinics of North America·Colin M ParsonsVijay P Khatri
Jul 11, 2006·Clinics in Dermatology·Serge A JabbourRonni Wolf
Jan 13, 2006·International Journal of Pediatric Otorhinolaryngology·Evan R RansomSpiros Manolidis
Oct 22, 2015·Archives of Disease in Childhood. Education and Practice Edition·B M Dunning-Davies, A P J Parker
Jun 9, 2004·Neuroimaging Clinics of North America·Bruce R Korf
Mar 29, 2013·American Journal of Obstetrics and Gynecology·Anna R TerryScott R Plotkin
Aug 12, 2010·Cancer Biology & Therapy·Hua LiMargaret Wallace
Apr 30, 2002·Journal of Biomedical Informatics·W Sujansky
Apr 17, 2015·Nature Reviews. Cancer·Nancy Ratner, Shyra J Miller
Dec 11, 2013·The Journal of Pediatrics·Urania DagalakisBrigitte C Widemann
Sep 13, 2005·International Journal of Obstetric Anesthesia·J E SpiegelP E Hess
Oct 31, 2002·Journal of Child Neurology·Bruce R Korf
Oct 31, 2002·Journal of Child Neurology·Tena Rosser, Roger J Packer
Sep 28, 2001·British Journal of Anaesthesia·N P HirschJ J Radcliffe
Dec 22, 2017·Orphanet Journal of Rare Diseases·Rafaela E Rozza-de-MenezesKarin S Cunha
Sep 19, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·George Q PerrinDavid Muir
Sep 1, 1999·American Journal of Medical Genetics·B R Korf
Oct 19, 1999·The Journal of Urology·M M WaltherW M Linehan
Jun 14, 2006·The Journal of Craniofacial Surgery·Spiros ManolidisLarry H Hollier
Mar 30, 2007·Molecular Carcinogenesis·Lauren FishbeinMargaret R Wallace
Jul 20, 2007·Journal of Genetic Counseling·Heather B RadtkeGretchen Schneider
Feb 9, 2018·Orphanet Journal of Rare Diseases·Ashley CannonBruce Korf
May 16, 2008·American Journal of Medical Genetics. Part a·Therese M RothKate F Barald
Apr 25, 2019·American Journal of Medical Genetics. Part a·Jussi LeppävirtaSirkku Peltonen
Dec 23, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kimberly Jett, Jan M Friedman
Nov 28, 2018·Nature Communications·Jean-Philippe BrosseauLu Q Le

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.