Neurofibromatosis types 1 and 2: cranial MR findings

Radiology
S AokiD Norman

Abstract

Neurofibromatosis 1 (NF-1) (von Rekhlinghausen disease) and neurofibromatosis 2 (NF-2) (bilateral acoustic neurofibromatosis) have been recently recognized to be distinct disorders through genetic linkages. The authors compared the cranial magnetic resonance (MR) images of 53 patients with NF-1 and 11 with NF-2. In the NF-1 group, MR imaging revealed 19 patients with optic gliomas and eight with parenchymal gliomas. In 32 patients, foci of prolonged T2, similar to those reported previously as hamartomas, were identified in the cerebellar peduncles, globus pallidus, midbrain, and other locations. The frequency of these foci was related to both age and the presence of optic gliomas. In the NF-2 group, MR imaging revealed eight patients with cranial nerve schwannomas and six with meningiomas (in addition to acoustic schwannomas in all 11). These findings demonstrate that NF-1 and NF-2 are different diseases requiring different imaging protocols. NF-1 seems to be associated with tumors of astrocytes and neurons and NF-2 with tumors of meninges and Schwann cells.

Citations

Jul 1, 1996·Pediatric Radiology·S Van EsM De Silva
Mar 12, 2004·American Journal of Ophthalmology·Grant T LiuLeslie N Sutton
Feb 16, 2005·Clinical Radiology·R I Aviv, K Miszkiel
Mar 27, 2001·Indian Journal of Pediatrics·J R ShahH Parmer
Jun 10, 2010·Clinical Neuroradiology·E HattingenS Weidauer
Jul 20, 2007·Journal of Genetic Counseling·Heather B RadtkeGretchen Schneider
Jun 11, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Michaela GstöttnerAndreas Neher
Jan 1, 1994·Neuroradiology·P Akeson, S Holtås
Jan 1, 1992·Neuroradiology·C BegesN Martin
Jan 1, 1992·Neuroradiology·N MartinH Nahum
Dec 18, 2001·Topics in Magnetic Resonance Imaging : TMRI·T Y Poussaint
Mar 1, 1992·American Journal of Medical Genetics·B G Kousseff
Nov 22, 2013·Der Radiologe·A Zimmer
Aug 17, 2006·Pediatric Radiology·Deepak S GillKathryn N North
Aug 4, 2004·European Radiology·Hans-J MentzelWerner A Kaiser
Nov 1, 1995·European Journal of Radiology·M M PlantetC Mayras
Jan 30, 2004·European Journal of Radiology·W Müller-Forell
Dec 31, 2002·Clinical Imaging·R N SenerA A Veinbergs
May 14, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shunsuke NakakuraTakeya Kohno
Jun 2, 2005·Neuroimaging Clinics of North America·Alfred L WeberNelson R Sabates
Feb 7, 2012·Radiología·D Gorostiza LabordaB Iturre Salinas
Apr 20, 2011·Journal of the Neurological Sciences·Deniz YerdelenMehmet Karakas
Apr 24, 2010·European Journal of Radiology·Minerva BeckerChristoph D Becker
Sep 23, 2008·Pediatric Neurology·Kana Ram JatVivek Gupta
May 27, 2008·European Journal of Radiology·P S GohS Amrith
Aug 19, 2004·American Journal of Medical Genetics. Part a·Michael A KrautWalter E Kaufmann
Nov 5, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J P Curtin, S W McCarthy
Apr 1, 1992·Clinical Imaging·M Castillo, R Dominguez
Sep 1, 1991·European Journal of Radiology·B DuvoisinS Bobin
Nov 1, 1991·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·F MiharaB G Haik
Jul 5, 2006·Seminars in Pediatric Neurology·James H Tonsgard
Apr 28, 2006·Pediatric Neurology·Angelo AmmendolaEduardo Ammendola
Mar 1, 1992·Oral Surgery, Oral Medicine, and Oral Pathology·J R GeistS J Stefanac
Apr 1, 1990·Seminars in Roentgenology·B H BraffmanR A Zimmerman
Feb 23, 1999·Radiologic Clinics of North America·M D HollanderL M Tartaglino
Nov 16, 2002·Neurologic Clinics·Timothy M Lynch, David H Gutmann

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