Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis

Journal of Neuroinflammation
Irene HåkanssonJan Ernerudh

Abstract

There is a need for clinically useful biomarkers of disease activity in clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS). The aim of this study was to assess the correlation between neurofilament light chain (NFL) in cerebrospinal fluid (CSF) and serum and the relationship between NFL and other biomarkers, subsequent disease activity, and brain volume loss in CIS and RRMS. A panel of neurodegenerative and neuroinflammatory markers were analyzed in repeated CSF samples from 41 patients with CIS or RRMS in a prospective longitudinal cohort study and from 22 healthy controls. NFL in serum was analyzed using a single-molecule array (Simoa) method. "No evidence of disease activity-3" (NEDA-3) status and brain volume (brain parenchymal fraction calculated using SyMRI®) were recorded during 4 years of follow-up. NFL levels in CSF and serum correlated significantly (all samples, n = 63, r 0.74, p < 0.001), but CSF-NFL showed an overall stronger association profile with NEDA-3 status, new T2 lesions, and brain volume loss. CSF-NFL was associated with both new T2 lesions and brain volume loss during follow-up, whereas CSF-CHI3L1 was associated mainly with brain volume loss and CXCL1, CXCL10, CXCL13, CCL22, and MMP-9 w...Continue Reading

References

Mar 1, 1994·Journal of Neuroscience Methods·L E RosengrenL Hagberg
Jan 24, 2006·Lancet Neurology·Robert A Bermel, Rohit Bakshi
Apr 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A MoreiraA L Teixeira
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B M WarntjesP Lundberg
Jan 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Jonatan SalzerPeter Sundström
Feb 1, 2011·Annals of Neurology·Martin GunnarssonJan Lycke
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Sep 15, 2012·AJNR. American Journal of Neuroradiology·M VågbergA Svenningsson
Mar 26, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Veronica PopescuUNKNOWN MAGNIMS Study Group
Feb 24, 2015·Multiple Sclerosis : Clinical and Laboratory Research·G HinsingerE Thouvenot
Mar 4, 2015·Multiple Sclerosis : Clinical and Laboratory Research·M Alba Mañé MartínezHenrik Zetterberg
Jul 22, 2015·Multiple Sclerosis and Related Disorders·Gavin GiovannoniMonica Marta
Nov 21, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Ludwig KapposDavorka Tomic
Feb 18, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Robert ZivadinovDana Horakova
Aug 16, 2016·Neurology·Georgina ArrambideMar Tintore
Oct 5, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J MellergårdJ Ernerudh
Dec 18, 2016·Neurology·Maria A RoccaMassimo Filippi
Feb 6, 2017·Neurology·Benedetta Bodini, Peter Arthur Calabresi
Mar 7, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I HåkanssonJ Ernerudh
Apr 11, 2017·Neuroimaging Clinics of North America·Jaume Sastre-GarrigaÀlex Rovira
May 18, 2017·Annals of Neurology·Giulio DisantoUNKNOWN Swiss Multiple Sclerosis Cohort Study Group
Sep 6, 2017·Journal of the Neurological Sciences·Piotr IwanowskiElżbieta Kaufman
Dec 7, 2017·Neurology. Neuroimmunology and Neuroinflammation·Kristin N VarhaugChristian Vedeler
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Mar 4, 2018·Cold Spring Harbor Perspectives in Medicine·Anu PaulRoopali Gandhi
May 23, 2018·Revue neurologique·E Thouvenot

❮ Previous
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Citations

Jul 18, 2019·Arquivos de neuro-psiquiatria·Renan Barros DominguesCarlos Senne
Jun 28, 2019·Practical Neurology·Daniel CastleEmma C Tallantyre
Jan 16, 2020·Lab on a Chip·Alessandro ChiadòFrancesca Frascella
Jan 23, 2020·Brain Sciences·Kate L LambertsenHelle H Nielsen
Dec 11, 2019·Current Pharmaceutical Design·Yichen LeeBak-Sau Yip
Apr 25, 2020·Expert Review of Neurotherapeutics·Paolo PreziosaMassimo Filippi
May 15, 2020·Brain : a Journal of Neurology·Arie R GafsonPaul M Matthews
Jun 13, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Ellen IacobaeusUNKNOWN 2018 ECTRIMS Focused Workshop Group
May 18, 2020·Acta Neurologica Scandinavica·Daniel JonsOluf Andersen
May 27, 2020·Annals of Clinical and Translational Neurology·Mattia RossoTanuja Chitnis
Aug 23, 2020·Neurology. Neuroimmunology and Neuroinflammation·Saúl ReyesSharmilee Gnanapavan
Sep 16, 2020·Neurology. Neuroimmunology and Neuroinflammation·Makoto Matsui
Jun 27, 2020·Scientific Reports·Simon ThebaultMark S Freedman
Apr 27, 2019·Frontiers in Neurology·Kristin N VarhaugChristian A Vedeler
Mar 9, 2019·Annals of Clinical and Translational Neurology·Alissa RothmanPeter A Calabresi
Nov 27, 2019·Neurodegenerative Disease Management·Jiwon OhCatherine Larochelle
Mar 27, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Jae-Won HyunHo Jin Kim
Feb 19, 2020·Journal of Neuroinflammation·Marta Moreno-RodriguezElliott J Mufson
Sep 26, 2020·Neurology. Neuroimmunology and Neuroinflammation·Orhan AktasIris-Katharina Penner
Nov 5, 2020·Annals of Clinical and Translational Neurology·Christian BarroHoward L Weiner
Nov 12, 2020·Neurology. Neuroimmunology and Neuroinflammation·Ruth SchneiderAiden Haghikia
Jan 13, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Rocco CapuanoElena H Martinez-Lapiscina
Jan 22, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mattia RossoTanuja Chitnis
Aug 31, 2020·Multiple Sclerosis and Related Disorders·L NovakovaJ Lycke
Dec 9, 2020·Multiple Sclerosis and Related Disorders·C BridelC E Teunissen
Jan 7, 2021·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Krista D DiSanoAndrew R Pachner
May 8, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mehdi HassanpourYunes Panahi
Apr 24, 2021·Frontiers in Neuroscience·Carolina Ferreira-AtuestaSharmilee Gnanapavan
May 1, 2021·Scientific Reports·Paulette Esperanza Walo-DelgadoLuisa María Villar
May 11, 2021·Neurodegenerative Disease Management·José Meca-LallanaAlfredo Rodríguez-Antigüedad Zarranz
Jun 8, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jarmila SzilasiovaEva Stevens
Jun 12, 2021·Journal of Veterinary Internal Medicine·Taesik YunByeong-Teck Kang
Jul 9, 2021·Journal of Neuroscience Methods·Christian Barro, Henrik Zetterberg
Aug 17, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Igal RosensteinJan Lycke

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Methods Mentioned

BETA
ELISA
ELISAs

Software Mentioned

MasterPlex® Reader Fit
MEDCALC®
SPSS
xPONENT
SyMRI®

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