Neurofilament light chain predicts risk of recurrence in cerebral amyloid angiopathy-related intracerebral hemorrhage.

Aging
Xin ChengQiang Dong

Abstract

Predicting recurrent intracerebral hemorrhage (ICH) related to cerebral amyloid angiopathy (CAA) currently relies on brain images. We aimed to investigate whether blood neurodegenerative biomarkers predict disease severity and ICH recurrence in CAA. We recruited 68 first probable CAA-ICH cases from a Chinese prospective cohort, and 95 controls. We used the single-molecule array to measure acute phase blood amyloid-40, amyloid-42, total tau and neurofilament light chain (NfL). We used multivariable Cox regression models to assess the association between blood biomarkers and CAA-ICH recurrence, and used the concordance (c-) index to assess prediction models. Blood amyloid-42/40, total tau, and NfL levels changed in CAA-ICH cases than controls. During a median follow-up of 2.4 years, NfL was associated with CAA-ICH recurrence (adjusted hazard ratio 2.14, 95% CI 1.57-2.93) independent of MRI burden of small vessel disease (SVD). The performance of a model to predict CAA-ICH recurrence using MRI burden of SVD alone (c-index 0.77) increased with the addition of NfL (c-index 0.88, 95% CI 0.73-1.00, p=0.019). Further, NfL was associated with baseline ICH volume, NIHSS and 6-month mRS score. Blood NfL is associated with severity and pro...Continue Reading

References

May 20, 2000·Annals of the New York Academy of Sciences·S M GreenbergG W Rebeck
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·L O WahlundUNKNOWN European Task Force on Age-Related White Matter Changes
Apr 10, 2004·Stroke; a Journal of Cerebral Circulation·Steven M GreenbergJonathan Rosand
Nov 4, 2011·Nature Reviews. Neuroscience·Berislav V Zlokovic
Jan 21, 2012·Neuro-degenerative Diseases·Mar Hernandez-GuillamonJoan Montaner
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Sep 2, 2015·JAMA : the Journal of the American Medical Association·Alessandro BiffiJonathan Rosand
May 28, 2016·Current Neurovascular Research·Chunyan LeiQuantao Zeng
Mar 21, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Li XiongAnand Viswanathan
Oct 20, 2017·Neurology·Thomas GattringerMichael Khalil
Sep 2, 2018·Nature Reviews. Neurology·Michael KhalilJens Kuhle
Sep 10, 2018·Annals of Neurology·Inge M W VerberkWiesje M van der Flier
Oct 10, 2018·Nature Reviews. Neurology·Harald HampelKaj Blennow
Feb 21, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Andreas CharidimouAnand Viswanathan
Aug 3, 2019·Neurology·Suzanne E SchindlerRandall J Bateman
Dec 13, 2019·Nature Reviews. Neurology·Steven M GreenbergSusanne J van Veluw
Apr 20, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Daoshen LiuZhirong Liu

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Citations

May 23, 2021·Lancet Neurology·Xin Cheng, Qiang Dong
Jun 23, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ya SuXin Cheng

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