PMID: 2115070Aug 1, 1990Paper

Neurofilament proteins are distributed in a diminishing proximodistal gradient along rat sciatic nerve

Journal of Neurochemistry
W W Schlaepfer, J Bruce

Abstract

Neurofilament (NF) proteins are distributed in a diminishing proximodistal gradient along rat sciatic nerve when compared with total noncollagen or other proteins in nerve. About a twofold decline of NF proteins can be detected by quantitating nerve proteins that have been separated by gel electrophoresis. A similar decrease of immunoreactivity to each NF subunit is seen in distal nerve segments when noncollagen nerve proteins are immunoblotted. Parallel decreases occur in all three NF proteins, thereby maintaining neurofilament subunit stoichiometry along the neuraxis. The same NF gradient can be detected when the NF contents in nerve branches to the gluteus and gastrocnemius muscles are compared with each other and with those in nerve segments taken from the same proximodistal levels of the parent sciatic nerve. The gradient of NF proteins increases during postnatal development and is readily detected by postnatal day 16. During the same period of development, the heavy NF subunit appears for the first time and is rapidly incorporated throughout the sciatic nerve. Hence, the NF gradient becomes manifest during the development and maturation of the adult form of the axonal cytoskeleton. The basis for the proximodistal gradient...Continue Reading

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Citations

Sep 24, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Gerald M Higa
Nov 1, 1996·The Journal of Cell Biology·J R MarszalekD W Cleveland
Feb 4, 2010·Journal of Neurotrauma·Nurettin CengizElif Kaval Oğuz
Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aidong YuanRalph A Nixon
Feb 17, 2005·Neurotoxicology·Richard M LoPachinMaria L Reid
Jul 25, 2015·PloS One·Aidong YuanRalph A Nixon
May 29, 2016·Journal of Chemical Neuroanatomy·Matthew T K Kirkcaldie, Jessica M Collins
Apr 5, 2017·Cold Spring Harbor Perspectives in Biology·Aidong YuanRalph A Nixon
Sep 7, 2002·The Journal of Biological Chemistry·Weiwen GeRafaela Canete-Soler
Feb 1, 1992·Current Opinion in Cell Biology·R A Nixon
Sep 1, 1991·Journal of Neuroscience Research·T Tashiro, Y Komiya

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