Neurofilament proteins in axonal regeneration and neurodegenerative diseases

Neural Regeneration Research
Haitao WangYingpu Li

Abstract

Neurofilament protein is a component of the mature neuronal cytoskeleton, and it interacts with the zygosome, which is mediated by neurofilament-related proteins. Neurofilament protein regulates enzyme function and the structure of linker proteins. In addition, neurofilament gene expression plays an important role in nervous system development. Previous studies have shown that neurofilament gene transcriptional regulation is crucial for neurofilament protein expression, especially in axonal regeneration and degenerative diseases. Post-transcriptional regulation increased neurofilament protein gene transcription during axonal regeneration, ultimately resulting in a pattern of neurofilament protein expression. An expression imbalance of post-transcriptional regulatory proteins and other disorders could lead to amyotrophic lateral sclerosis or other neurodegenerative diseases. These findings indicated that after transcription, neurofilament protein regulated expression of related proteins and promoted regeneration of damaged axons, suggesting that regulation disorders could lead to neurodegenerative diseases.

Citations

Nov 23, 2018·Molecular Neurobiology·Tainá M MarquesMarcel M Verbeek
Apr 21, 2017·Frontiers in Neurology·Elizabeth A MillsYang Mao-Draayer
Jan 11, 2020·Frontiers in Neuroscience·Aaron GilmourRylie A Green
Mar 9, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Fahsai KantawongYoung-Tae Chang
May 11, 2021·Frontiers in Neurology·Gerard Janez Brett ClarkeAsta Kristine Håberg

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Methods Mentioned

BETA
electron microscopy
glycosylation
electrophoresis
transfection
transgenic

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