Neurofilaments in disease: what do we know?

Current Opinion in Neurobiology
Brian A Gordon

Abstract

Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has drastically increased as recent advances have made it possible to measure levels in both the cerebrospinal fluid and blood. There is mounting evidence that neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (NfH) are abnormal in a host of neurodegenerative diseases. In this review we examine how both of these proteins behave across diseases and what we know about how these biomarkers relate to in vivo white matter pathology and each other.

Citations

Jan 21, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C B TauilL L Dos Santos-Neto
Dec 15, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Andrew Eisen, David Taylor
Jun 12, 2020·Neurobiology of Disease·Stephanie A SchultzUNKNOWN Dominantly Inherited Alzheimer Network
Apr 18, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jérémy RaffinUNKNOWN MAPT/DSA Group
Jul 16, 2021·Chemico-biological Interactions·David Hernandez-Toledano, Libia Vega
Jul 16, 2021·Annals of Clinical and Translational Neurology·Daniele SabbatiniGianni Sorarù

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