Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke

The International Journal of Neuroscience
Morgana M NovaesDraulio Araujo

Abstract

Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). TMS and fMRI were used to investigate 15 stroke survivors immediately before and after a single 30-min MT session. We found statistically significant increase in post-MT motor evoked potential (MEP) amplitude (increased excitability) from the affected primary motor cortex (M1), when compared to pre-MT MEP. Post-MT fMRI maps were associated with a more organized and constrained pattern, with a more focal M1 activity within the affected hemisphere after MT, limited to the cortical area of hand representation. Furthermore, we find a change in the balance of M1 activity toward the affected hemisphere. In addition, significant correlation was found between decreased fMRI β-values and increased MEP amplitude post-MT, in the affected hemisphere. Our study suggests that a single MT i...Continue Reading

References

Apr 22, 1996·Proceedings. Biological Sciences·V S Ramachandran, D Rogers-Ramachandran
Sep 1, 1996·Stroke; a Journal of Cerebral Circulation·J DesrosiersM Guay
Dec 1, 1996·Stroke; a Journal of Cerebral Circulation·G RapisardaP J Delwaide
Dec 31, 1997·Stroke; a Journal of Cerebral Circulation·S C CramerB R Rosen
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·Y CaoK M Welch
Jun 22, 1999·Lancet·E L AltschulerV S Ramachandran
Mar 23, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J LiepertC Weiller
Jan 4, 2001·American Journal of Physical Medicine & Rehabilitation·C E LevyD W Chakeres
Mar 7, 2001·Neurorehabilitation and Neural Repair·K SathianS L Wolf
Mar 26, 2002·Brain : a Journal of Neurology·James R CareyKamil Ugurbil
Jul 24, 2002·Brain : a Journal of Neurology·Toshio ShimizuPaolo M Rossini
Aug 26, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Mar 3, 2004·Annals of Neurology·Nagako MuraseLeonardo G Cohen
Mar 9, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adriana Bastos ConfortoAlain Kaelin-Lang
May 1, 2004·Yonsei Medical Journal·Yun-Hee KimPeter K W Lee
Dec 15, 2004·Archives of Neurology·Nick S Ward, Leonardo G Cohen
Apr 29, 2006·Stroke; a Journal of Cerebral Circulation·Yun DongCarolee J Winstein
Jul 7, 2007·The International Journal of Neuroscience·Kenji FukumuraYutaka Tomita
Dec 23, 2008·Arquivos de neuro-psiquiatria·Sonia M Fioravanti CarvalhoDraulio B de Araujo
Aug 14, 2010·Stroke; a Journal of Cerebral Circulation·Kelley C Mazzetto-BettiDraulio B de Araujo
Aug 24, 2010·Acta Neurologica Scandinavica·B B Johansson
Sep 24, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Marian E MichielsenRuud W Selles
Nov 6, 2010·Neurorehabilitation and Neural Repair·Marian E MichielsenJohannes B J Bussmann
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ippei NojimaToshio Kawamata
Sep 10, 2014·Archives of Physical Medicine and Rehabilitation·David A CunninghamEla B Plow
Dec 4, 2014·Human Brain Mapping·Michele VeldsmanAmy Brodtmann
Jun 23, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kamal Narayan AryaVinod Puri
Apr 19, 2016·Science Translational Medicine·Claire AllmanHeidi Johansen-Berg

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Citations

Aug 28, 2020·Frontiers in Human Neuroscience·Umar Muhammad BelloChetwyn C H Chan

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