Neurofunctional Correlates of Response to Quetiapine in Adolescents with Bipolar Depression

Journal of Child and Adolescent Psychopharmacology
Kiki D ChangManpreet Singh

Abstract

Prior studies have shown that youth with bipolar disorder demonstrate neurofunctional changes in key prefrontal and subcortical brain regions implicated in emotional regulation following treatment with pharmacological agents. We recently reported a large response rate (>60%) to quetiapine (QUET) for treating depressive symptoms in adolescents with bipolar depression. This study investigates the neurofunctional effects of QUET using functional magnetic resonance imaging (fMRI). Thirty-three unmedicated subjects, 10-17 years of age, with a current depressive episode (Children's Depression Rating Scale-Revised [CDRS-R] > 40) associated with bipolar I or II disorder were recruited in a two-site randomized, placebo (PBO)-controlled trial of QUET monotherapy for treatment of bipolar depression in adolescents. Twenty-three of these participants (nine male) underwent an MRI scan at baseline, then were randomized to QUET or PBO, followed for 8 weeks, and at the end of their study participation underwent another MRI scan. During the fMRI scan, subjects viewed negative and neutral pictures and rated the valence of each picture. Sixteen subjects had usable data at both time points: 10 subjects randomized to QUET, and 6 randomized to PBO. F...Continue Reading

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Citations

Aug 4, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Manpreet K SinghDavid J Miklowitz
Feb 23, 2021·Expert Opinion on Pharmacotherapy·Ahmad Sleem, Rif S El-Mallakh

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Software Mentioned

ArtRepair
Eprime
QUET
SPSS
Psychology
MarsBar
SPM5

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