Neurofunctional effects of developmental alcohol exposure in alcohol-preferring and alcohol-nonpreferring rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Maria TattoliVincenzo Cuomo

Abstract

The neurofunctional effects of developmental alcohol exposure (3% v/v solution from day 15 of gestation to day 7 after parturition) have been investigated in Sardinian alcohol-preferring (sP) and alcohol-nonpreferring (sNP) rat lines, selectively bred for opposite alcohol preference and consumption. Alcohol exposure significantly decreased the rate of ultrasonic emission in sP male pups; whereas, it did not affect this indicator of emotional reactivity in sNP animals. Perinatal alcohol intake did not influence either learning of an active avoidance task or hippocampal long-term potentiation in both offspring lines. Significant differences in time spent exploring novel objects were observed between control sP and sNP rats subjected to the novel exploration object test. Alcohol exposed sP rats, but not alcohol exposed sNP rats, apparently lost the capacity to discriminate between the novel and the familiar object, even though this difference is difficult to interpret because of the large differences in the respective responses to the novel objects. Neurochemical experiments have shown that basal levels of dopamine (DA) and homovanillic acid (HVA) were significantly higher in the nucleus accumbens (NAC) of sP rats with respect to ...Continue Reading

Citations

Jun 28, 2003·Neurotoxicity Research·Claudio A NaranjoLescia K Tremblay
Oct 3, 2006·Neuroscience and Biobehavioral Reviews·M Gabriela ChotroGiovanni Laviola
Jul 26, 2014·The European Journal of Neuroscience·Wendy L ComeauJoanne Weinberg
Jan 31, 2019·Frontiers in Behavioral Neuroscience·Takahira ShirahaseMasaki Tanaka

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