Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Iris M BalodisMarc N Potenza

Abstract

Although reward processing appears altered in addiction, few studies track neurofunctional changes following treatment or relate these to measures of reduced drug use. The current study examined neurofunctional alterations in reward processing in cocaine dependence (CD) pretreatment and posttreatment to determine whether these changes relate to clinically meaningful outcome indicators. Treatment-seeking CD outpatients (N=29) underwent functional magnetic resonance imaging while performing a monetary incentive delay task (MIDT) pretreatment and posttreatment. The MIDT parses anticipatory from outcome phases of reward/loss processing. Abstinence indicators (negative urines, days abstinent from cocaine during follow-up) were collected throughout treatment and up to 1 year later. Healthy control (HC) participants (N=28) were also scanned twice with the MIDT. Relative to pretreatment, at posttreatment CD participants demonstrated increased anticipatory reward activity in the midbrain, thalamus, and precuneus (pFWE<0.05). Increased midbrain activity correlated with cocaine abstinence during the 1-year follow-up. Ventral striatal (VS) activity during loss anticipation correlated negatively with negative urine screens. HC group test-re...Continue Reading

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Citations

Oct 30, 2016·Drug and Alcohol Dependence·Sarah E ForsterJoshua W Brown
Jan 21, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna S HuangRita Z Goldstein
Aug 24, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rita A Fuchs, Ryan J McLaughlin
Aug 9, 2017·Journal of Clinical Psychopharmacology·Anders JørgensenHenrik Berg Rasmussen
Nov 28, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniela VázquezMatthew R Roesch
Sep 19, 2018·Attention Deficit and Hyperactivity Disorders·Sarah BaumeisterDaniel Brandeis
Oct 5, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hestia MoningkaSarah W Yip
Dec 5, 2019·NeuroImage. Clinical·Jennifer L StewartMartin P Paulus
Mar 23, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Scott J Moeller, Martin P Paulus
Apr 7, 2021·The International Journal of Neuropsychopharmacology·Simon ZhornitskySheng Zhang
Aug 14, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Linda J PorrinoMichael A Nader

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