Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells

Biochemical and Biophysical Research Communications
Abhishek ChandraNaoyuki Miura

Abstract

Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously isolated the Neurogenesin-1 (Ng1) gene and found that Ng1 protein induces neuronal differentiation in the brain. In this study, we found that Ng1 was expressed in the primordial cells of the skeleton and investigated whether Ng1 protein inhibited the BMP action to induce osteoblastic differentiation in C2C12 myoblasts. Interestingly, Ng1 protein inhibited the BMP7-induced alkaline phosphatase activity while it did not inhibit the BMP2-induced activity. All data suggest that Ng1 protein plays an important role in the embryonic bone formation by differentially regulating BMPs.

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Citations

Apr 10, 2009·Journal of the American Society of Nephrology : JASN·Barry W LarmanLeif Oxburgh
Oct 27, 2009·FEBS Letters·Hiroyuki MiwaNobuyuki Itoh
Aug 1, 2021·Metabolism: Clinical and Experimental·Gabriel S JensenKristy L Townsend

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